{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:07:11Z","timestamp":1784156831000,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atherosclerosis is a multi\u2010system pathology with heterogeneous involvement.<\/jats:p><jats:p>We aimed to investigate the relationship between the presence and severity of carotid and coronary calcification in a group of patients with coronary artery disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010three patients presenting with unstable angina or positive stress test for myocardial ischaemia were enrolled in this study. All patients underwent CT scanning of the carotid and coronary arteries using the conventional protocol and Agatston scoring system. Risk factors for atherosclerosis were also analyzed for correlation with the extent of arterial calcification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total coronary artery calcium score (CAC) was several times higher than total carotid calcium score (1274 (1018) <jats:italic>vs<\/jats:italic> 6 (124), <jats:italic>p<\/jats:italic>\u00a0=\u00a00\u00b70001, respectively). The left carotid calcium score correlated strongly with the right carotid calcium score (rho\u00a0=\u00a00\u00b769, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00\u00b70001). The total CAC score correlated modestly with the total carotid calcium score (rho\u00a0=\u00a00\u00b734, <jats:italic>p<\/jats:italic>\u00a0=\u00a00\u00b7007), in particular with left carotid score (rho\u00a0=\u00a00\u00b738, <jats:italic>p<\/jats:italic>\u00a0=\u00a00\u00b7002), but not with the right carotid score. The left coronary calcium score correlated with the right coronary calcium score (rho\u00a0=\u00a00\u00b735, <jats:italic>p<\/jats:italic>\u00a0=\u00a00\u00b7004), left carotid calcium score (rho\u00a0=\u00a00\u00b733, <jats:italic>p<\/jats:italic>\u00a0=\u00a00\u00b7007) and left carotid calcium score at the bifurcation (rho\u00a0=\u00a00\u00b734, <jats:italic>p<\/jats:italic>\u00a0=\u00a00\u00b7006). While hypertension correlated with carotid calcium score, diabetes and dyslipidaemia correlated with left CAC score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with coronary disease, the carotid calcification pattern appeared to be similar between the right and left system in contrast to that of the coronary arteries. CAC correlated only modestly with the carotid score, despite being significantly higher. Hypertension was related to carotid calcium score while diabetes and dyslipidaemia correlated with coronary calcification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12694","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T14:56:33Z","timestamp":1613314593000},"page":"271-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The relationship between carotid and coronary calcification in patients with coronary artery disease"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2243-2053","authenticated-orcid":false,"given":"Rafik","family":"Shenouda","sequence":"first","affiliation":[{"name":"International Cardiac Centre \u2010 ICC Alexandria Egypt"},{"name":"Department of Public Health and Clinical Medicine Umea University Umea Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Vancheri","sequence":"additional","affiliation":[{"name":"Radiology Department I.R.C.C.S. Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Maria Bassi","sequence":"additional","affiliation":[{"name":"Radiology Department I.R.C.C.S. Policlinico San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Nicoll","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Umea University Umea Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Sobhi","sequence":"additional","affiliation":[{"name":"International Cardiac Centre \u2010 ICC Alexandria Egypt"},{"name":"Cardiology Department Faculty of medicine Alexandria University Sharqi Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"El Sharkawy","sequence":"additional","affiliation":[{"name":"International Cardiac Centre \u2010 ICC Alexandria Egypt"},{"name":"Cardiology Department Faculty of medicine Alexandria University Sharqi Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Wester","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Umea University Umea Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-063X","authenticated-orcid":false,"given":"Federico","family":"Vancheri","sequence":"additional","affiliation":[{"name":"Internal Medicine Department S.Elia Hospital Caltanissetta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Henein","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Umea University Umea Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21088"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz486"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.12.1344"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003920070098"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20150094"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.2013.46"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.3.7304"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.05.934"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.10.013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-012-0051-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/aic.2019.90216"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.08.081"},{"issue":"6","key":"e_1_2_6_15_1","first-page":"668","article-title":"Current understanding of coronary artery calcification","volume":"12","author":"Liu W.","year":"2015","journal-title":"Journal of Geriatric Cardiology"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/49957752"},{"issue":"1","key":"e_1_2_6_18_1","first-page":"57","article-title":"Molecular biology of atherosclerosis","volume":"5","author":"Mannarino E.","year":"2008","journal-title":"Clinical Cases in Mineral and Bone Metabolism : The Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.18585\/inabj.v10i2.479"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.3.2772178"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2014.09.017"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001424"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.17987\/icfj.v1i1.10"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091481"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.07.007"},{"issue":"2","key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"e0144182","DOI":"10.1371\/journal.pone.0144182","article-title":"Impact of cardiovascular risk factors on carotid intima\u2010media thickness and degree of severity: A cross\u2010sectional study","volume":"10","author":"Ren L.","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e318296aeca"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000232582.91028.03"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1258\/0007142001903265"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1355"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-013-0277-8"},{"key":"e_1_2_6_32_1","first-page":"28","article-title":"Coronary CT angiography with prospective ECG\u2010triggering: An effective alternative to invasive coronary angiography","volume":"2","author":"Sun Z.","year":"2012","journal-title":"Cardiovascular Diagnosis and Therapy"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i7.961"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01804.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.05.001"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.1175"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442721"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.12694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cpf.12694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.12694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T03:59:34Z","timestamp":1693540774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.12694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/cpf.12694"],"URL":"https:\/\/doi.org\/10.1111\/cpf.12694","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,26]]},"assertion":[{"value":"2020-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}