{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:04:58Z","timestamp":1783649098165,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/background<\/jats:title><jats:p>Transthyretin amyloid (ATTR) amyloidosis cardiomyopathy is an underdiagnosed, causatively treatable cause of heart failure (HF). The aim of this study was to evaluate the efficacy of electrocardiogram (ECG) and echocardiography on patients with increased interventricular septum diameter (IVSd) to identify ATTR cardiac amyloidosis (ATTR\u2010CA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated 58 patients with HF and an IVSd\u00a0&gt;\u00a014\u00a0mm. Included were 33 ATTR\u2010CA patients and 25 controls that consisted of non\u2010amyloidosis HFpatients with negative 99mTc\u20103,3\u2010diphosphono\u20101,2\u2010propanodicarboxylic acid (DPD) scintigraphy. We used echocardiography including 2D speckle\u2010tracking strain and a 12\u2010lead ECG to test the accuracy to differentiate the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found high diagnostic accuracy (98%) for differentiating ATTR\u2010CA from HF controls using a combination of R amplitude in \u2010aVR from ECG and relative wall thickness acquired from echocardiography. With this combined model (RWT\/R in \u2010aVR), the sensitivity was 100% and specificity was 95% using a cut\u2010off value of 0.90. Furthermore, the area under the curve was 99% and the negative predictive value was 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that a simple combination of ECG and echocardiographic parameters used in clinical settings was able to differentiate ATTR\u2010CA from other aetiologies of HF with increased interventricular septum thickness. The high sensitivity and negative predictive value render the algorithm useful for selection of patients for further diagnostic procedures for ATTR\u2010CA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12715","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T15:29:15Z","timestamp":1621956555000},"page":"408-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Combining ECG and echocardiography to identify transthyretin cardiac amyloidosis in heart failure"],"prefix":"10.1111","volume":"41","author":[{"given":"Viktor","family":"L\u00f6fbacka","sequence":"first","affiliation":[{"name":"Heart Centre, Clinical Physiology Department of Surgical and Perioperative Sciences Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole B.","family":"Suhr","sequence":"additional","affiliation":[{"name":"Medicine Department of Public Health and 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