{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:49:45Z","timestamp":1773175785354,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Primary Raynaud's phenomenon (pRP) is characterized by an exaggerated response to cold, resulting in the whitening typically of the fingers and toes. The patients are generally perceived as healthy individuals with a benign condition. However, the condition has been associated with increased cardiovascular mortality and changes in autonomic nervous system activity. This study aimed to investigate whether pRP is associated with pervasive changes in autonomic nervous activity. The hypothesis was that patients with pRP have increased sympathetic nervous activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The autonomic nervous activity of 22 patients with pRP was investigated by means of heart rate variability (HRV) and the plasma catecholamine response to head\u2010up tilt and compared with 22 age\u2010 and gender\u2010matched controls. In addition, the patients were examined with a [<jats:sup>123<\/jats:sup>I]metaiodobenzylguanidine heart scintigraphy and compared with an external control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The plasma norepinephrine response to head\u2010up tilt was significantly lower in the patient group than in the control group. Similarly, the heart scintigraphy revealed a lower heart\u2010to\u2010mediastinum ratio in the patient group than in the control group. HRV analysis did not reveal significant differences between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of the study showed that the autonomic nervous activity of patients with pRP was altered compared with the activity of healthy individuals. This was observed both during rest and after positional stress, but the findings did not uniformly concur with our initial hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12737","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T17:18:02Z","timestamp":1640971082000},"page":"104-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Autonomic nervous system activity in primary Raynaud's phenomenon: Heart rate variability, plasma catecholamines\u00a0and [<sup>123<\/sup>I]MIBG heart scintigraphy"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-8683","authenticated-orcid":false,"given":"Lotte","family":"Lindberg","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Herlev Hospital Copenhagen University Hospital Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise S.","family":"Brinth","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, North Zealand Hospital Copenhagen University Hospital Hiller\u00f8d Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne L.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Biochemistry and Immunology, Vejle Hospital University Hospital of Southern Denmark Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bent","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Herlev Hospital Copenhagen University Hospital Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine W.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen Gentofte Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Hasbak","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; 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