{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:20:56Z","timestamp":1778811656630,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with chest pain may have normal coronary arteries and suffer from microvascular angina (MVA). The aim of this study was to determine if patients with suspected MVA have lower global myocardial perfusion (global MP) during adenosine stress compared with healthy controls and coronary artery disease (CAD) patients and to determine if there are sex differences in global MP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three patients with suspected MVA (66\u2009\u00b1\u200911 years), 19 CAD patients (69\u2009\u00b1\u20095 years) with stress\u2010induced ischaemia and 24 healthy controls (61\u2009\u00b1\u200910 years) underwent cardiac magnetic resonance (CMR) including coronary sinus flow measurements and first\u2010pass perfusion at rest and during adenosine stress. Global MP was quantified as coronary sinus flow normalized to left ventricular mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Global perfusion was lower during stress in patients with suspected MVA (2.9\u2009\u00b1\u20091.0\u2009ml\/min\/g) compared with healthy volunteers (3.7\u2009\u00b1\u20091.1\u2009ml\/min\/g, <jats:italic>p<\/jats:italic>\u2009=\u20090.018), but higher compared with CAD patients (2.0\u2009\u00b1\u20090.9\u2009ml\/min\/g, <jats:italic>p<\/jats:italic>\u2009=\u20090.019). Female controls had higher global MP than male controls both at rest (1.0\u2009\u00b1\u20090.3 vs. 0.7\u2009\u00b1\u20090.2\u2009ml\/min\/g, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and during stress (4.4\u2009\u00b1\u20091.0 vs. 3.1\u2009\u00b1\u20090.6\u2009ml\/min\/g, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Furthermore, females with suspected MVA showed higher global MP than males with suspected MVA (3.3\u2009\u00b1\u20091.0 vs. 2.4\u2009\u00b1\u20090.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with suspected MVA have lower global MP at stress than healthy volunteers but higher than patients with CAD. Furthermore, there seems to be a sex difference in global MP at stress both in healthy volunteers and in patients with suspected MVA, with higher global MP in females, which implies a need for sex\u2010specific normal limits when assessing quantitative MP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12750","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T04:09:15Z","timestamp":1647144555000},"page":"208-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Myocardial perfusion by CMR coronary sinus flow shows sex differences and lowered perfusion at stress in patients with suspected microvascular angina"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-3514","authenticated-orcid":false,"given":"Tom","family":"Gyllenhammar","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Lund University and Sk\u00e5ne University 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