{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:25:15Z","timestamp":1790043915773,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Decreased cardiorespiratory fitness (CRF) related to cardiopulmonary function increases the risk of cardiovascular disease in patients with end\u2010stage kidney disease. Thus, early detection of the cause of impaired cardiopulmonary function in patients undergoing peritoneal dialysis (PD) is of important clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, symptom\u2010restricted cardiopulmonary exercise testing (CPET) was performed in 30 patients undergoing PD and in 23 age\u2010 and sex\u2010matched healthy control subjects. A fixed workload was added every minute until fatigue, and breath\u2010by\u2010breath respiratory gas was analysed with an automated gas analyzer at 10\u2010s intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The peak oxygen uptake (16.39\u2009\u00b1\u20090.83 vs. 25.77\u2009\u00b1\u20091.33\u2009ml\/kg\/min <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the oxygen uptake at the anerobic threshold of patients undergoing PD (9.61\u2009\u00b1\u20090.34 vs. 14.55\u2009\u00b1\u20090.64\u2009ml\/kg\/min; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were lower than in healthy control subjects, and both of these parameters correlated with body mass index and left atrial dimension. A steeper minute ventilation\/carbon dioxide production slope (27.20\u2009\u00b1\u20090.68 vs. 24.29\u2009\u00b1\u20090.69\uff1b<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and a lower end\u2010tidal carbon dioxide partial pressure (37.93\u2009\u00b1\u20090.54 vs. 41.27\u2009\u00b1\u20090.83\u2009mmHg\uff1b<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) were observed in patients undergoing PD. The oxygen pulse and oxygen uptake efficiency slope was smaller in patients undergoing PD. The Maximum heart rate (126.07\u2009\u00b1\u20094.01 vs. 149.96\u2009\u00b1\u20095.29\u2009bpm\uff1b<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and 1\u2010min heart rate recovery (13.93\u2009\u00b1\u20091.52 vs. 24.39\u2009\u00b1\u20091.61\u2009bpm\uff1b<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were also lower in patients undergoing PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subclinical cardiopulmonary dysfunction may exist in patients with PD, and a reduction in CRF in patients undergoing PD is affected by both central and peripheral functions. CPET has potential value in revealing the mechanism of impaired CRF and in discovering subclinical abnormalities in cardiopulmonary function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12756","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T05:52:50Z","timestamp":1649915570000},"page":"269-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiopulmonary exercise testing to observe subclinical abnormalities in cardiopulmonary function in patients undergoing peritoneal dialysis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-5399","authenticated-orcid":false,"given":"Xin","family":"Wu","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Xuzhou Medical University, Rehabilitation  Xuzhou Jiangsu 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