{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T11:34:52Z","timestamp":1772019292040,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008484","name":"Paavo Nurmen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010133","name":"Aarne Koskelon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007753","name":"It\u00e4-Suomen Yliopisto","doi-asserted-by":"publisher","award":["Doctoral School"],"award-info":[{"award-number":["Doctoral School"]}],"id":[{"id":"10.13039\/100007753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with coronary artery disease (CAD), ischaemic cardiomyopathy may result in progressive cardiac remodelling and left ventricular (LV) dysfunction. Myocardial perfusion imaging (MPI) can be used to quantify LV size and shape, mechanical dyssynchrony (LVMD) and ejection fraction (EF) as well as myocardial ischaemia and injury extents. We investigated the prevalence of LV remodelling (LVR) in patients with CAD and the relationship between LVR, LVMD and EF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred twenty\u2010six\u00a0patients with CAD were evaluated. The EF and end\u2010diastolic volume (EDV) were measured using MPI. LVMD was assessed using phase analysis. LVR was characterised according to LV dilatation or increased shape indices (systolic shape index\u00a0[SIES] and\u00a0diastolic shape index [SIED]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LVR were observed in 41% of CAD patients. EDV, SIES and SIED were larger in patients with LVMD or low EF. After adjustment for age, sex and infarct and ischaemia extents, phase histogram bandwidth correlated with EDV (<jats:italic>r<\/jats:italic>\u2009=\u20090.218) and SIES (<jats:italic>r<\/jats:italic>\u2009=\u20090.266) and EF correlated with EDV (<jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.535), SIES (<jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.554) and SIED (<jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.217, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LVR is frequently seen in patients with CAD and may be detected even before the development of symptomatic heart failure. A large LV volume and a more spherical\u2010shaped LV were associated with LVMD and low EF, highlighting the close relationships between remodelling and systolic dyssynchrony and dysfunction. MPI is useful for assessing LVR by providing information about LV size and shape, which changes from an ellipsoid towards a spherical form in the development of ischaemic cardiomyopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12780","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T08:58:55Z","timestamp":1658134735000},"page":"413-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-2689","authenticated-orcid":false,"given":"Hanna","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Kuopio University Hospital Kuopio Finland"},{"name":"Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina M.","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja","family":"Hedman","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"},{"name":"Department of Cardiothoracic Surgery Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Hedman","sequence":"additional","affiliation":[{"name":"Heart Center Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Kivel\u00e4","sequence":"additional","affiliation":[{"name":"Heart Center Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-9957","authenticated-orcid":false,"given":"Tomi P.","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Kuopio University Hospital Kuopio Finland"},{"name":"Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2006.05.020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310052"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2015-000246"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1739-7"},{"key":"e_1_2_9_6_1","first-page":"298","article-title":"Improvement in left ventricular intrinsic dyssynchrony with cardiac resynchronization therapy","volume":"17","author":"Bozyel S.","year":"2017","journal-title":"Anatolian Journal of Cardiology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001878"},{"key":"e_1_2_9_8_1","volume-title":"Quanitative Perfusion SPECT (QPS), Reference Manual","author":"Cedars\u2010Sinai Medical Center","year":"2011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-011-9392-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-017-1090-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-017-0777-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-017-0862-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.14503\/THIJ-13-3585"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-020-02316-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12379"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-015-0388-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu361"},{"key":"e_1_2_9_18_1","first-page":"1441","article-title":"Clinical validation of automatic quantitative defect size in rest technetium\u201099m\u2010sestamibi myocardial perfusion SPECT","volume":"38","author":"Kang X.P.","year":"1997","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-09975-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.03.091"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-017-1009-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-019-01465-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","unstructured":"Phan D. 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