{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:09:26Z","timestamp":1790208566633,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Positron emission tomography\u2010computed tomography (PET\u2010CT) using prostate\u2010specific membrane antigen (PSMA) ligands is a method for imaging prostate cancer. A recent tracer, <jats:sup>18<\/jats:sup>F\u2010PSMA\u20101007, offers advantages concerning production and biokinetics compared to the standard tracer (<jats:sup>68<\/jats:sup>Ga\u2010PSMA\u201011). Until now, radiation dosimetry data for this ligand was limited to the material of three healthy volunteers. The purpose of this study is to study the biokinetics and dosimetry of <jats:sup>18<\/jats:sup>F\u2010PSMA\u20101007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve patients with prostate cancer were injected with 4\u2009MBq\/kg <jats:sup>18<\/jats:sup>F\u2010PSMA\u20101007. Eight PET\u2010CT scans with concomitant blood sampling were performed up to 330\u2009min after injection. Urine was collected until the following morning. Volumes of interest for radiation\u2010sensitive organs and organs with high uptake of <jats:sup>18<\/jats:sup>F\u2010PSMA\u20101007 were drawn in the PET images. A biokinetic compartment model was developed using activity data from PET images and blood and urine samples. Time\u2010activity curves and time\u2010integrated activity coefficients for all delineated organs were calculated. The software IDAC\u2010dose 2.1 was used to calculate the absorbed and effective doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High concentrations of activity were noted in the liver, kidneys, parts of the small intestine, spleen, salivary glands, and lacrimal glands. The elimination through urine was 8% of injected activity in 20\u2009h. The highest absorbed doses coefficients were in the lacrimal glands, kidneys, salivary glands, liver, and spleen (98\u201366\u2009\u00b5Gy\/MBq). The effective dose coefficient was 25\u2009\u00b5Sv\/MBq.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The effective dose of <jats:sup>18<\/jats:sup>F\u2010PSMA\u20101007 is 6.0\u20138.0\u2009mSv for a typical patient weighing 80\u2009kg injected with 3\u20134\u2009MBq\/kg.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12785","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T10:12:33Z","timestamp":1661854353000},"page":"443-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biokinetics and dosimetry of <sup>18<\/sup>F\u2010PSMA\u20101007 in patients with prostate cancer"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-2921","authenticated-orcid":false,"given":"Erland","family":"Hvittfeldt","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Wallenberg Centre for Molecular Medicine Lund University  Lund Sweden"},{"name":"Department of Translational Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8715-507X","authenticated-orcid":false,"given":"Mimmi","family":"Bj\u00f6ersdorff","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Wallenberg Centre for Molecular Medicine Lund University  Lund Sweden"},{"name":"Department of Translational Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustav","family":"Brolin","sequence":"additional","affiliation":[{"name":"Wallenberg Centre for Molecular Medicine Lund University  Lund Sweden"},{"name":"Department of Translational Medicine Lund University  Lund Sweden"},{"name":"Department of Radiation Physics Sk\u00e5ne University Hospital  Malm\u00f6 and Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Minarik","sequence":"additional","affiliation":[{"name":"Wallenberg Centre for Molecular Medicine Lund University  Lund Sweden"},{"name":"Department of Translational Medicine Lund University  Lund Sweden"},{"name":"Department of Radiation Physics Sk\u00e5ne University Hospital  Malm\u00f6 and Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid L.","family":"Svegborn","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University  Lund Sweden"},{"name":"Department of Radiation Physics Sk\u00e5ne University Hospital  Malm\u00f6 and Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Oddstig","sequence":"additional","affiliation":[{"name":"Wallenberg Centre for Molecular Medicine Lund University  Lund Sweden"},{"name":"Department of Translational Medicine Lund University  Lund Sweden"},{"name":"Department of Radiation Physics Sk\u00e5ne University Hospital  Malm\u00f6 and Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-303X","authenticated-orcid":false,"given":"Elin","family":"Tr\u00e4g\u00e5rdh","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Wallenberg Centre for Molecular Medicine Lund University  Lund Sweden"},{"name":"Department of Translational Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-017-0339-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11030552"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3182859751"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0146645316661077"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0096"},{"key":"e_1_2_8_7_1","first-page":"1014","volume-title":"European Journal of Nuclear Medicine and Molecular Imaging","author":"Fendler W.P.","year":"2017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3502389"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3573-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.212233"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.12.051"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30314-7"},{"key":"e_1_2_8_13_1","first-page":"5","article-title":"Basic anatomical and physiological data for use in radiological protection: reference values. 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