{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:44:26Z","timestamp":1759178666338,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In cirrhosis, cardiac systolic dysfunction as part of cirrhotic cardiomyopathy\u00a0affects prognosis. Myocardial mechano\u2010energetic efficiency (MEE) is an estimate of left ventricular performance. In this study we investigated the relation of MEE to patient characteristics and its impact on survival in patients with cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We included 283 patients with cirrhosis of different severity according to the Child\u2212Pugh classifications (A\/B\/C: 106\/87\/90). All patients had a liver vein catheterization and a hemodynamic investigation performed including determination of cardiac output (CO), stroke volume\u00a0and heart rate (HR). These data were used to assess MEE, which was defined as (stroke volume\/HR)\u2009\u00d7\u20091.666.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010nine percent of patients had portal hypertension (hepatic venous pressure gradient &gt;5\u2009mmHg) and 80% indications of hyperdynamic circulatory state (increased CO and HR). There was no difference in MEE in Child\u2212Pugh class C patients (2.03) versus Child\u2212Pugh class A (1.98) and B (2.05) patients. In Child\u2212Pugh class C patients, low MEE was associated with a poorer prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study, MEE does not seem to be associated with severity of the liver disease, but in patients with advanced disease low MEE is associated with a poorer prognosis. The prognostic impact of MEE should be further investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12789","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T12:54:37Z","timestamp":1663937677000},"page":"28-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of low mechano\u2010energetic efficiency and prognosis in liver cirrhosis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-5204","authenticated-orcid":false,"given":"Sannia","family":"Sj\u00f6stedt","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine 260, Center of Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Signe","family":"Wiese","sequence":"additional","affiliation":[{"name":"Gastro Unit, Medical Division 360, Hvidovre Hospital, Faculty of Health Sciences University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Gastro Unit, Medical Division 360, Hvidovre Hospital, Faculty of Health Sciences University of Copenhagen Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine 260, Center of Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2017.12.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040321"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002198"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29520"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16305"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494820911802"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2021.01.012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30875"},{"key":"e_1_2_9_11_1","unstructured":"Kassambara A. 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