{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T15:39:01Z","timestamp":1742398741690,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001554","name":"Massey University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During hyperthermia, the perturbations in mean arterial blood pressure (MAP) produced by the Valsalva manoeuvre (VM) are more severe. However, whether these more severe VM\u2010induced changes in MAP are translated to the cerebral circulation during hyperthermia is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy participants (<jats:italic>n<\/jats:italic>\u2009=\u200912, 1 female, mean\u2009\u00b1\u2009SD: age 24\u2009\u00b1\u20093 years) completed a 30\u2009mmHg (mouth pressure) VM for 15\u2009s whilst supine during normothermia and mild hyperthermia. Hyperthermia was induced passively using a liquid conditioning garment with core temperature measured via ingested temperature sensor. Middle cerebral artery blood velocity (MCAv) and MAP were recorded continuously during and post\u2010VM. Tieck's autoregulatory index was calculated from the VM responses, with pulsatility index, an index of pulse velocity (pulse time) and mean MCAv (MCAv<jats:sub>mean<\/jats:sub>) also calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Passive heating significantly raised core temperature from baseline (37.9\u2009\u00b1\u20090.2 vs. 37.1\u2009\u00b1\u20090.1\u00b0C at rest, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). MAP during phases I through III of the VM was lower during hyperthermia (interaction effect <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Although an interaction effect was observed for MCAv<jats:sub>mean<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), post\u2010hoc differences indicated only phase IIa was lower during hyperthermia (55\u2009\u00b1\u200912 vs. 49.3\u2009\u00b1\u20098\u2009cm\u2009s<jats:sup>\u2212<\/jats:sup><jats:sup>1<\/jats:sup> for normothermia and hyperthermia, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Pulsatility index was increased 1\u2010min post\u2010VM in both conditions (0.71\u2009\u00b1\u20090.11 vs. 0.76\u2009\u00b1\u20090.11 for pre\u2010 and post\u2010VM during normothermia, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.02, and 0.86\u2009\u00b1\u20090.11 vs. 0.99\u2009\u00b1\u20090.09 for hyperthermia <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), although for pulse time only main effects of time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and condition (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were apparent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data indicate that the cerebrovascular response to the VM is largely unchanged by mild hyperthermia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12843","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T06:03:20Z","timestamp":1687154600000},"page":"463-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebrovascular and cardiovascular responses to the Valsalva manoeuvre during hyperthermia"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-519X","authenticated-orcid":false,"given":"Blake G.","family":"Perry","sequence":"first","affiliation":[{"name":"School of Health Sciences, College of Health Massey University Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Korad","sequence":"additional","affiliation":[{"name":"School of Health Sciences, College of Health Massey University Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby","family":"M\u00fcndel","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Nutrition, College of Health Massey University Palmerston North New Zealand"},{"name":"Department of Kinesiology Brock University St Catharines Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.087320"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.172023"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00475.2009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"17","article-title":"Human cardiovascular responses to passive heat stress","volume":"5","author":"Crandall C.G.","year":"2011","journal-title":"Comprehensive 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