{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:07:38Z","timestamp":1768691258900,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004817","name":"Lund University Medical Faculty Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myocardial perfusion SPECT\u00a0(MPS) and exercise electrocardiography\u00a0(Ex\u2010ECG) results are of prognostic importance for short\u2010term follow up duration. However, the value of MPS or Ex\u2010ECG findings for long\u2010term risk assessment is less evident as underlying risk factors for ischemic heart disease (IHD) gain in importance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the short\u2010 and long\u2010term prognostic value of MPS and Ex\u2010ECG in relation to known risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>An observational study of 908 patients (age 63 years, 49% male, 45% prior IHD) referred for MPS and Ex\u2010ECG. Follow\u2010up was divided into two periods (short\u2010term: &lt;5 years and long\u2010term: &gt;5 years). Cardiac events were defined as a composite of acute myocardial infarction, unstable angina, unplanned revascularization and cardiovascular death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The composite endpoint occurred in 95 patients (short\u2010term follow up) and in 94 patients (long\u2010term follow up). In multivariable models stress testing had a strong predictive value for short\u2010term follow up (HR for MPS\u2009=\u20092.9, CI\u2009=\u20091.9\u20134.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and HR for Ex\u2010ECG\u2009=\u20092.1, CI 1.3\u20133.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), but no predictive value for long\u2010term follow up (HR for MPS\u2009=\u20090.9, CI\u2009=\u20090.5\u20131.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.70 and HR for Ex\u2010ECG\u2009=\u20091.0, CI\u2009=\u20090.6\u20131.6, <jats:italic>p<\/jats:italic>\u2009=\u20090.92). Male sex and prior IHD were significant predictors regardless of follow up duration. Age, diabetes and decreased exercise capacity were risk factors for long\u2010term follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prognostic value of MPS and Ex\u2010ECG results are strong for short\u2010term follow up but diminish over time and do not contribute significantly in multivariable models after 5 years. Long\u2010term prognosis is primarily governed by underlying risk factors and exercise capacity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12899","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T13:13:59Z","timestamp":1723986839000},"page":"454-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Short\u2010 and long\u2010term prognostic performance of exercise ECG and myocardial perfusion SPECT"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-4766","authenticated-orcid":false,"given":"M.","family":"Kraen","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Clinical Physiology, Sk\u00e5ne University Hospital Lund University Lund 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