{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T18:56:11Z","timestamp":1762109771831,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>There is a scarcity of information regarding the effect of upper\u2010body eccentric exercise on biomarkers of muscle damage. This study sought to investigate the effect of eccentric arm cycling on muscle damage [exercise\u2010induced muscle damage (EIMD)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Ten subjects performed a 15\u2009min eccentric arm cycling protocol (cadence 49\u2009\u00b1\u20097\u2009rpm, power absorbed 248\u2009\u00b1\u200934\u2009W). Maximal voluntary contraction (MVC) of the elbow flexors was evaluated at rest and at 5\u2009min, 24\u2009h, and 48\u2009h post\u2010exercise. In addition, blood samples were drawn at rest and thereafter at 30\u2009min, 24\u2009h, and 48\u2009h intervals after exercise for quantification of creatine kinase (CK), myoglobin, lactate dehydrogenase (LDH) and endothelin (ET\u20101) concentrations. Delayed onset muscle soreness (DOMS) was assessed using a category ratio scale (0\u201310).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Myoglobin was increased from baseline at 30\u2009min post\u2010exercise (+114%, 46.08\u2009\u00b1\u200922.17\u2009\u00b5g\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.018). Individual peak values were higher than baseline values for CK (+72.8%, 204\u2009\u00b1\u2009138\u2009U\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.046) and LDH (+17%, 3.3\u2009\u00b1\u20090.88\u2009nmole\/min\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.017), but not for ET\u20101 (+9%, 1.4\u2009\u00b1\u20090.48\u2009pg\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.45). DOMS was reported at 24\u2009h (median 4) and 48\u2009h (median 4) post\u2010exercise and MVC of the elbow flexors were reduced from baseline (216\u2009\u00b1\u200944\u2009N) at 5\u2009min (\u221234%, 147\u2009\u00b1\u200961\u2009N, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), 24\u2009h (\u221217%, 181\u2009\u00b1\u200956\u2009N, <jats:italic>p<\/jats:italic>\u2009=\u20090.005) and 48\u2009h (\u22129%, 191\u2009\u00b1\u200954\u2009N, <jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Eccentric arm cycling incites EIMD with reduced MVC and elevation of myoglobin, CK and LDH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.12911","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T06:24:06Z","timestamp":1728887046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of eccentric arm cycling on 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Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-0733","authenticated-orcid":false,"given":"Antonis","family":"Elia","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology KI Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199112030-00004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/960363"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00548.2010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112079"},{"volume-title":"Borg's perceived exertion and pain scales","year":"1998","author":"Borg 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