{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:46:28Z","timestamp":1764103588886,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although numerous techniques exist for renal blood flow (RBF) estimation, none of the methods have been implemented in routine clinical practice due to their inadequacies and burdensomeness. Previously, we evaluated rubidium\u201082 (<jats:sup>82<\/jats:sup>Rb) positron emission tomography\/computed tomography (PET\/CT) for renal perfusion determination and found strong indications of method precision and reliability. The aim of this study was to compare renal <jats:sup>82<\/jats:sup>Rb clearance with renal technetium\u201099m\u2010mercaptoacetyltriglycine ([<jats:sup>99m<\/jats:sup>Tc]Tc\u2010MAG3) clearance as a first attempt to validate <jats:sup>82<\/jats:sup>Rb PET\/CT for renal perfusion estimation using a reference method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten subjects with essential hypertension underwent two treatment periods, receiving spironolactone and placebo in random order. At the end of each period, each subject completed a <jats:sup>82<\/jats:sup>Rb PET\/CT scan and a [<jats:sup>99m<\/jats:sup>Tc]Tc\u2010MAG3 clearance study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:sup>82<\/jats:sup>Rb clearance correlated positively with [<jats:sup>99m<\/jats:sup>Tc]Tc\u2010MAG3 clearance in both treatment periods. The [<jats:sup>99m<\/jats:sup>Tc]Tc\u2010MAG3\u2010to\u2010<jats:sup>82<\/jats:sup>Rb clearance ratio was 0.83 and 0.86 in the placebo and spironolactone treatment periods, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The correlation between <jats:sup>82<\/jats:sup>Rb clearance and [<jats:sup>99m<\/jats:sup>Tc]Tc\u2010MAG3 clearance may indicate that PET\/CT determined <jats:sup>82<\/jats:sup>Rb clearance can act as an estimator of renal perfusion. The [<jats:sup>99m<\/jats:sup>Tc]Tc\u2010MAG3\u2010to\u2010<jats:sup>82<\/jats:sup>Rb clearance ratios suggest that the extraction fraction of <jats:sup>82<\/jats:sup>Rb is higher than that of [<jats:sup>99m<\/jats:sup>Tc]Tc\u2010MAG3, further suggesting <jats:sup>82<\/jats:sup>Rb clearance as an estimator of flow. However, further studies are warranted to validate use of <jats:sup>82<\/jats:sup>Rb PET\/CT for flow estimation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.70000","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T01:16:39Z","timestamp":1740532599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Renal clearance estimated by rubidium\u201082 positron emission tomography\/computed tomography and technetium\u201099m\u2010mercaptoacetyltriglycine clearance infusion technique"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-7283","authenticated-orcid":false,"given":"Stine Sundgaard","family":"Langaa","sequence":"first","affiliation":[{"name":"University Clinic in Nephrology and Hypertension, Department of Medicine G\u00f8dstrup Hospital and Aarhus University Herning 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