{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:21Z","timestamp":1753878381850,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the efficacy of pulmonary blood volume (PBV) as a marker of the cardiac hyperemic response to adenosine during myocardial perfusion imaging (MPI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty healthy subjects underwent four consecutive Rubidium\u201082 rest\/adenosine\u2010stress MPI: two sessions were conducted without any caffeine consumption (baseline), while the remaining two sessions involved controlled caffeine consumption (arm 1: 100 and 300\u2009mg; arm 2: 200 and 400\u2009mg). We evaluate the ability of the stress\u2010to\u2010rest ratio of PBV (PBV ratio) to identify an adequate cardiac hyperemic response. The adequate hyperemic response was defined as a stress myocardial blood flow &gt;2\u2009mL\/g\/min and a corresponding myocardial flow reserve &gt;68% of the maximum myocardial flow reserve obtained during the baseline scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on 126 MPI sessions conducted in 40 subjects, the PBV ratio demonstrated a sensitivity of 78% and a specificity of 74% in detecting adequate cardiac hyperemia. The positive predictive value was 95%, while the negative predictive value was 36%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The PBV ratio permits the identification of adequate hyperemic response with sensitivities and specificities comparable to existing markers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.70001","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:23:52Z","timestamp":1740561832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary blood volume as a marker of adenosine\u2010induced cardiac hyperemia: A Rubidium\u201082 study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-0146","authenticated-orcid":false,"given":"Martin Lyngby","family":"Lassen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine University Hospital Copenhagen \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences, Cluster for Molecular Imaging University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob Peter","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine University Hospital Copenhagen \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences Copenhagen Denmark"},{"name":"Centre for Physical Activity Research University Hospital Copenhagen \u2013 Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine University Hospital Copenhagen \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences, Cluster for Molecular Imaging University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan M. G.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine University Hospital Copenhagen \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences Copenhagen Denmark"},{"name":"Centre for Physical Activity Research University Hospital Copenhagen \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Neurovascular Research Laboratory Faculty of Life Sciences and Education University of South Wales Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine University Hospital Copenhagen \u2013 Rigshospitalet Copenhagen Denmark"},{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences, Cluster for Molecular Imaging University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Hasbak","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine University Hospital Copenhagen \u2013 Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1007\/s12350-018-1269-9"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.2967\/jnumed.116.180448"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1007\/s12350-020-02140-1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1007\/s12350-016-0522-3"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1002\/jmri.25032"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1007\/s12350-022-02906-9"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1007\/s12350-023-03308-1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.2967\/jnumed.121.261970"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1007\/s12350-022-02946-1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1007\/s00259-007-0478-2"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.2967\/jnumed.117.201368"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1007\/s12350-018-1332-6"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1016\/j.jacc.2006.12.015"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.3389\/fpubh.2017.00307"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.70001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T03:13:34Z","timestamp":1743304414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.70001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/cpf.70001"],"URL":"https:\/\/doi.org\/10.1111\/cpf.70001","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"type":"print","value":"1475-0961"},{"type":"electronic","value":"1475-097X"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"2024-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70001"}}