{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:30Z","timestamp":1787014050720,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n It remains to be established whether it provides any clinical or diagnostic benefits to perform ventilation\/perfusion (V\/Q) scintigraphy as a single photon emission computed tomography in children. Here, we report our experience with this modality, evaluate its impact on clinical decision\u2010making and assess its interrater agreement.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n All V\/Q scintigraphies performed in children over a 1\u2010year period were identified, and patient files were reviewed. Two nuclear medicine physicians, blinded to patient data and each other's readings, interpreted all scintigraphies.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 20 planar and SPECT V\/Q scintigraphies were identified. In 17\/20 cases (85%), the results of the scan were found to directly inform clinical decision\u2010making. SPECT mainly ruled out the presence of ventilation and perfusion defects that were suspected on planar scintigraphy. In terms of interrater agreement, Cohen's\n \u03f0<\/jats:italic>\n coefficients for planar ventilation and perfusion scintigraphy were 0.34 and 0.38 (fair agreement), respectively, while the corresponding values for SPECT were 0.42 and 0.61 (moderate to substantial agreement).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n It is both feasible and clinically meaningful to perform V\/Q SPECT in children. In this patient group, V\/Q SPECT furthermore seems to have better interrater agreement than planar scintigraphy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cpf.70012","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:45:15Z","timestamp":1749170715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ventilation\/perfusion SPECT in children: Feasibility, impact on clinical decision\u2010making and interrater agreement"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1000-3534","authenticated-orcid":false,"given":"Lise","family":"Borgwardt","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Louise","family":"M\u00f8rk","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Gutte","sequence":"additional","affiliation":[{"name":"Department of Radiology Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Kiil","family":"Berthelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"de Nijs","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-9506","authenticated-orcid":false,"given":"Ronan M. G.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Centre for Physical Activity Research Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jann","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2013Rigshospitalet Copenhagen Denmark"},{"name":"Department of Medicine The National Hospital Torshavn Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04450-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00286770"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0485-3"},{"key":"e_1_2_9_5_1","unstructured":"European Association of Nuclear Medicine. Dosage calculator [Internet].2019. Available fromhttps:\/\/www.eanm.org\/publications\/dosage-calculator"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.9.696"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-54-643-576"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283336747"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2018.10.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000001314"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2018.10.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3282f25905"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13869"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.70012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T17:04:50Z","timestamp":1764435890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.70012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/cpf.70012"],"URL":"https:\/\/doi.org\/10.1111\/cpf.70012","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]},"assertion":[{"value":"2024-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70012"}}