{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:07:59Z","timestamp":1790208479375,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The biodistribution of PSMA\u2010ligands is of interest in radionuclide therapy planning. We investigated the variability of [\n                      <jats:sup>18<\/jats:sup>\n                      F]PSMA\u20101007 uptake in organs at risk and in relation to tumour burden in prostate cancer patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 1086 patients who underwent PSMA PET\u2010CT for staging or recurrence of prostate cancer were included. Total lesion volume (TLV) and total lesion uptake (TLU) were calculated from manual segmentations. The mean standardized uptake value (SUV\n                      <jats:sub>mean<\/jats:sub>\n                      ) in the organs at risk kidneys, liver, parotid glands and spleen was obtained. Correlations between TLV\/TLU and SUV\n                      <jats:sub>mean<\/jats:sub>\n                      in normal tissues were calculated using Spearman rank correlation. SUV\n                      <jats:sub>mean<\/jats:sub>\n                      in normal tissues was stratified into groups based on TLV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median (IQR) SUV\n                      <jats:sub>mean<\/jats:sub>\n                      of the kidneys, liver, parotid glands, and spleen was 13.1 (IQR 4.6), 11.8 (4.4), 18.6 (6.8) and 11.3 (5.8), respectively. The median TLV was 3.8\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      (9.7) and median TLU was 31.2\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      (106.3). There was no significant correlation between TLV or TLU and SUV\n                      <jats:sub>mean<\/jats:sub>\n                      for the liver, parotid glands, or spleen, but a weak negative correlation between TLV\/TLU and SUV\n                      <jats:sub>mean<\/jats:sub>\n                      in the kidneys (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.011,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). There was a tendency towards a lower SUV\n                      <jats:sub>mean<\/jats:sub>\n                      in the kidneys and parotid glands in patients with a very high TLV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was a large uptake variability in organs at risk, which demonstrates the need for individual pretherapy dosimetry. There may be a tumour sink effect in the kidneys and parotid glands in patients with a very high TLV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.70016","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T11:03:43Z","timestamp":1749985423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of [18F]PSMA\u20101007 uptake variability in patients with prostate cancer"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-303X","authenticated-orcid":false,"given":"Elin","family":"Tr\u00e4g\u00e5rdh","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Translational Medicine and Wallenberg Center for Molecular Medicine Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3137-1405","authenticated-orcid":false,"given":"M\u00e5ns","family":"Larsson","sequence":"additional","affiliation":[{"name":"Eigenvision AB Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8129-3228","authenticated-orcid":false,"given":"David","family":"Minarik","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Wallenberg Center for Molecular Medicine Lund University Malm\u00f6 Sweden"},{"name":"Department of Radiation Physics Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7456-1009","authenticated-orcid":false,"given":"Olof","family":"Enqvist","sequence":"additional","affiliation":[{"name":"Eigenvision AB Malm\u00f6 Sweden"},{"name":"Chalmers University of Technology Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Edenbrandt","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7245"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/wjnm.WJNM_54_19"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1937-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.11.15.22282357"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-06089-w"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.178228"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3413\/Nukmed-0937-17-10"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19049"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.261906"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3573-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30198-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12785"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359231157632"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3125-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06255-8"},{"key":"e_1_2_10_17_1","unstructured":"NPL. (n.d.) Calibration factors for the NPL \u2018Fidelis\u2019 Secondary Standard Radionuclide Calibrator. Version 3 Issued 13\/11\/2018. fidelis_ssrc_factors.pdf obtained from the websitehttps:\/\/www.npl.co.uk\/[Accessed 18th February 2025]."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12801"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018171356"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-019-01375-w"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S140671"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.70016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T17:04:43Z","timestamp":1764435883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.70016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,15]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/cpf.70016"],"URL":"https:\/\/doi.org\/10.1111\/cpf.70016","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,15]]},"assertion":[{"value":"2025-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70016"}}