{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:54:05Z","timestamp":1770515645491,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare measurements of skin perfusion pressure (SPP) and transcutaneous oxygen pressure (TcPO<jats:sub>2<\/jats:sub>) to predict postamputation wound healing according to amputation level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted as a prospective two\u2010centre, head\u2010to\u2010head study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two patients had SPP, TcPO<jats:sub>2<\/jats:sub> measured (below and above the knee), and toe and ankle blood pressure measurements taken before major amputation. Paired measurements of SPP and TcPO<jats:sub>2<\/jats:sub> were used to compare the methods. We found overall poor agreement between SPP and TcPO<jats:sub>2<\/jats:sub> measurements, with crude agreement below the knee in 32 of 45 limbs (71%) and above the knee in 17 of 23 limbs (74%), with \u03ba values of 0.32 and 0.13, respectively. Among the 29 patients whose SPP measurements below the knee indicated healing potential, seven were amputated above the knee. Blood pressure measurements above the cut\u2010off values (30\u2009mmHg for the toe and 80\u2009mmHg for the ankle, above 40\u2009mmHg SPP and TcPO<jats:sub>2<\/jats:sub> values), were seen as an indicator of high healing potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found poor (71%\u201374%) crude agreement between SPP and TcPO<jats:sub>2<\/jats:sub>, concerning measurements above and below the knee, using the established diagnostic cut\u2010offs for predicting a high probability of postamputation wound healing. We determined that SPP and TcPO<jats:sub>2<\/jats:sub> evaluate different physiological properties of the microcirculation and cannot be interchanged. Additionally, we found that the actual amputation level is often chosen at another level than that suggested by SPP and TcPO<jats:sub>2<\/jats:sub>, indicating that the choice is based on a multitude of factors, including clinical, paraclinical and patient\u2010related parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.70025","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T18:43:54Z","timestamp":1755542634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skin perfusion pressure, distal blood pressure vs. trans cutaneous oxygen pressure for predicting wound healing after major amputation"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-4500","authenticated-orcid":false,"given":"J. P.","family":"Paludan","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Viborg Regional Hospital Viborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-1680","authenticated-orcid":false,"given":"C.","family":"H\u00f8yer","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Viborg Regional Hospital Viborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"H\u00f8gh","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Viborg Regional Hospital Viborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-288X","authenticated-orcid":false,"given":"H. D.","family":"Zacho","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"},{"name":"Department of Nuclear Medicine Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3182876a06"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2011.12.004"},{"issue":"5","key":"e_1_2_9_4_1","first-page":"569","article-title":"Toe blood pressure by photoplethysmography: an index of healing in forefoot amputation","volume":"89","author":"Bone G.E.","year":"1981","journal-title":"Surgery"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2704"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X18769152"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11160"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.1992.32349"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453678909149326"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13202"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"43","article-title":"Transcutaneous oximetry in clinical practice: consensus statements from an expert panel based on evidence","volume":"36","author":"Fife C.E.","year":"2009","journal-title":"Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.06.052"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0094-1298(02)00066-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365517709100659"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296816658054"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20220128-05"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.62220"},{"issue":"6","key":"e_1_2_9_19_1","first-page":"865","article-title":"Predictive value of distal perfusion pressure in the healing of amputation of the digits and the forefoot","volume":"154","author":"Schwartz J.A.","year":"1982","journal-title":"Surgery, Gynecology & Obstetrics"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1824-4777.17.01296-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2016.01.012"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2022.2056857"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.10.045"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.70025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:45:19Z","timestamp":1758865519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.70025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/cpf.70025"],"URL":"https:\/\/doi.org\/10.1111\/cpf.70025","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,18]]},"assertion":[{"value":"2025-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70025"}}