{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T12:57:53Z","timestamp":1774184273341,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the reproducibility of diastolic function parameters from myocardial perfusion imaging (MPI) using ECG\u2010gated single photon emission computed tomography (SPECT), and echocardiography in repeated imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the reproducibility of MPI diastolic function parameters peak\u2010filling rate (PFR) and time to peak filling (TTPF) as well as echocardiographic parameters E\/A, E\/e', and E\u2010wave deceleration time (DT). The study population consisted of 21 patients who underwent routine MPI with repeated rest acquisition and echocardiography. In a test\u2013retest setting, appropriate diastolic measures were successfully obtained using SPECT in 20 patients, with E\/A measured in 18, E\/e' in 17, and DT in 16 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that PFR was well reproducible with the intraclass correlation coefficient (ICC) 0.887, and coefficient of variation (CV%) 10.5. However, TTPF was poorly reproducible (ICC 0.012, and CV% 17.5). E\/A was highly reproducible (ICC 0.963, and CV% 12.5). Decent reproducibility was observed for E\/e' (ICC 0.809, and CV% 18.6) and DT (ICC 0.833, and CV% 12.0). We further studied the correlation between these parameters. PFR (EDV\/s) had negative correlation with DT (r\u2009=\u2009\u22120.538, <jats:italic>p<\/jats:italic>\u2009=\u20090.039) and E\/A had positive with E\/\u00e9 (<jats:italic>r<\/jats:italic>\u2009=\u20090.689, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). No other significant correlations were observed (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05 for all). We also examined how parameters classified patients as normal or abnormal regarding the diastolic function. E\/A and E\/e\u00b4, as well as E\/A and PFR showed similar classifications in 88% of cases, with a Kappa value of 0.433, <jats:italic>p<\/jats:italic>\u2009=\u20090.074 for both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PFR obtained from repeated SPECT studies, along with the E\/A ratio, is highly reproducible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpf.70032","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T11:16:09Z","timestamp":1758712569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reproducibility of diastolic function parameters in repeated ECG\u2010gated SPECT myocardial perfusion imaging and echocardiography"],"prefix":"10.1111","volume":"45","author":[{"given":"Aaro","family":"Krohns","sequence":"first","affiliation":[{"name":"University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomi P.","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Center Kuopio University Hospital Kuopio Finland"},{"name":"Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina M.","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Center Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-3219","authenticated-orcid":false,"given":"Saara","family":"Sillanm\u00e4ki","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Center Kuopio University Hospital Kuopio Finland"},{"name":"Institute of Clinical Medicine University of Eastern Finland Kuopio 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