{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:48:32Z","timestamp":1764154112286,"version":"3.46.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate left atrial (LA) function assessed by peak atrial longitudinal strain (PALS) in an elderly population with silent paroxysmal atrial fibrillation (PAF) compared to age\u2010matched control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From the STROKESTOP2\u2010study, patients with newly diagnosed silent PAF were enrolled together in a randomly selected age\u2010matched control group. All patients had NT\u2010proBNP levels between 125 and 900\u2009ng\/L. Echocardiographic examinations were performed and analyzed offline using dedicated software. In addition to conventional echocardiographic variables, PALS was measured using a two\u2010dimensional speckle tracking (2D\u2010ST) biplane.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study population (mean age 76\u2009\u00b1\u20090.3) demonstrated significantly reduced PALS in patients with PAF (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200969) compared to controls (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200994) (23.9%\u2009\u00b1\u20096.5% vs 30.7%\u2009\u00b1\u20097.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the PAF group, 29 (42%) patients had normal LA volume index (LAVI) defined as 34\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      . When subgroups with normal LAVI were compared, PALS was reduced in PAF compared to controls (25.1\u2009\u00b1\u20098.0 vs 31.1\u2009\u00b1\u20097.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). NT\u2010proBNP levels did not differ between the PAF group (median 228\u2009ng\/L) and the control group (median: 217\u2009ng\/L) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.16). In multiple linear regression analysis, left ventricular global longitudinal strain, stroke volume index and LAVI were independent predictors of PALS. Receiver operating characteristic curve identified PALS threshold &lt;22% for predicting risk of silent PAF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PALS was significantly reduced in PAF patients even in the absence of significant LA remodeling. PALS &lt;22% predicts risk for silent PAF in general elderly population. In high\u2010risk patients PALS could be used for AF screening enrichment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.70035","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:49:58Z","timestamp":1762339798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Echocardiographic assessment of peak atrial longitudinal strain in paroxysmal atrial fibrillation patients compared to age\u2010matched controls"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7767-4159","authenticated-orcid":false,"given":"Larissa","family":"Bastos","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Danderyd Hospital, Karolinska Institutet Stockholm Sweden"},{"name":"Department Clinical Physiology Danderyd Hospital Stockholm 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Danderyd Hospital, Karolinska Institutet Stockholm Sweden"},{"name":"Department of Cardiology Danderyd Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kambiz","family":"Shahgaldi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Danderyd Hospital, Karolinska Institutet Stockholm Sweden"},{"name":"Department Clinical Physiology Danderyd Hospital Stockholm 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