{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:04:40Z","timestamp":1788422680609,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study evaluates mannitol as a clearance marker for measuring glomerular filtration rate (GFR) in outpatients with chronic kidney disease (CKD). Multi\u2010sample iohexol clearance served as the reference method. Twenty patients with CKD, stages 3\u20134, received bolus injections of both clearance markers simultaneously. Blood samples were collected 3, 5 and 22\u2009h after the bolus injections. Marker concentrations were analyzed using liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS). A calculation template, based on the Br\u00f6chner\u2013Mortensen multi\u2010sample model, was applied to determine GFR for both markers. In addition, plasma clearance of mannitol was assessed using the one\u2010sample Jacobsson equation, applied to samples taken 5 and 22\u2009h after the bolus injection of mannitol. Agreement between the clearance methods was assessed by the Bland\u2010Altman method, and the accuracy of mannitol clearance versus iohexol clearance was assessed by calculating P30 and P10. For the multi\u2010sample clearance, the between\u2010methods bias was 0.95\u2009\u00b1\u20091.4\u2009mL\/min\/1.73\u2009m\u00b2, the error was 10%, and the accuracy was 100% for both P30 and P10. The corresponding values for bias, error, P30 and P10 for the one\u2010sample plasma clearance of mannitol versus the reference method were: \u22122.3\u2009\u00b1\u20093.6 and 2.9\u2009\u00b1\u20093.0\u2009mL\/min\/1.73\u2009m\u00b2, 24% and 21%, 95% and 100%, 80% and 60%, respectively for samples obtained 5 and 22\u2009h after the bolus. Mannitol exhibited a reliable performance as a clearance marker in patients with CKD, stages 3\u20134, and may serve as an alternative when standard markers, iohexol or isotopes, are contraindicated. However, further large\u2010scale studies are required to confirm these findings.<\/jats:p>","DOI":"10.1111\/cpf.70059","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:50:06Z","timestamp":1775213406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clearance of mannitol for assessment of glomerular filtration rate in chronic kidney disease: A validation against iohexol clearance"],"prefix":"10.1111","volume":"46","author":[{"given":"Katalin","family":"Kiss","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aso","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Nephrology, Institute of Medicine, 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