{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T09:08:37Z","timestamp":1779872917004,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inhaled saline may improve mucus transport in respiratory diseases, for example, cystic fibrosis. This randomised, placebo\u2010controlled, crossover study examined the effect of inhaled dry NaCl on mucociliary clearance in patients with chronic obstructive pulmonary disease (COPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010five patients with GOLD stage I\u2010III COPD (72% with excess mucus) were tested on two separate days after inhalation from a dry powder inhaler containing either 40\u2009mg dry NaCl or placebo (empty). Pulmonary mucociliary clearance was assessed using inhalation of a radioactive\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010labelled nanocolloid tracer and gamma camera imaging. Clearance was measured for 2\u2009h post\u2010intervention. Co\u2010primary outcomes were clearance after 1 and 2\u2009h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study was terminated early due to COVID\u201019 after enrolling 25 of 35 planned patients. No significant differences were observed in mucociliary clearance between NaCl and placebo after 1\u2009h (11.3%\u2009\u00b1\u20099.0% vs. 11.4%\u2009\u00b1\u20097.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.97) or 2\u2009h (15.3%\u2009\u00b1\u20099.8% vs.16.1%\u2009\u00b1\u20098.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.55). Normalised clearance based on initial radioaerosol deposition also showed no difference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inhalation of 40\u2009mg dry NaCl was well tolerated without acute adverse effects in COPD patients. However, early termination left the study underpowered, increasing the risk of type II error. Non\u2010significant findings should not be interpreted as evidence of no effect. Larger, adequately powered trials are needed to clarify the impact of dry NaCl inhalation on mucociliary clearance in COPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.70060","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:45:28Z","timestamp":1775087128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo\u2010controlled, crossover study"],"prefix":"10.1111","volume":"46","author":[{"given":"Rie Skovly","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2014Rigshospitalet Copenhagen Denmark"},{"name":"Centre for Physical Activity Research, Copenhagen University Hospital\u2014Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2014Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naja Enevold","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2014Rigshospitalet Copenhagen Denmark"},{"name":"Department of Nuclear Medicine Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrefna S\u00e6unn","family":"Einarsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2014Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-7030","authenticated-orcid":false,"given":"Mohamed","family":"Attauabi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Copenhagen University Hospital\u2014Herlev and Gentofte Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan M. G.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2014Rigshospitalet Copenhagen Denmark"},{"name":"Centre for Physical Activity Research, Copenhagen University Hospital\u2014Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Harboe","sequence":"additional","affiliation":[{"name":"Liita Care ApS Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-8995","authenticated-orcid":false,"given":"Jann","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital\u2014Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Medicine The National Hospital Torshavn Faroe Islands"},{"name":"Faculty of Health Sciences University of the Faroe Islands Torshavn Faroe Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.129704"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091560"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028241"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm201710-1981ST"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09040725"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jam.2006.19.100"},{"key":"e_1_2_10_8_1","unstructured":"GOLD. 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