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Changes in native T1 and T2 reflect changes in myocardial perfusion; therefore, the aim of our study was to investigate whether non\u2010contrast, adenosine stress native T1 and T2 are affected in patients with previous suspected MINOCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Patients with MINOCA and a normal CMR (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915, 59\u2009\u00b1\u20097 years, 60% female) underwent 1.5T CMR together with age\u2010 and sex\u2010matched volunteers. The protocol included native T1, native T2 and quantitative perfusion mapping, at rest and during adenosine stress. Myocardial stress perfusion was globally reduced, both transmurally (2.9 \u00b1 0.9 vs. 3.6 \u00b1 0.7\u2009mL\/min\/g,\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.02) and in the subendocardium (2.64 \u00b1 0.81 vs. 3.47 \u00b1 0.78 ml\/min\/g,\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.008) in patients with MINOCA, with a reduced global ratio of subendocardial\u2010to\u2010transmural stress perfusion (0.921 \u00b1 0.042 vs 0.957 \u00b1 0.039,\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.021). However, there were no differences in global transmural rest native T1 or T2, stress native T1 or T2, or \u0394T1\u2010 or \u0394T2 values between patients and volunteers. Overall, transmural myocardial perfusion correlated with native T1 (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.27,\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001) and T2 (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.48,\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001) globally, and \u0394T1 correlated with the MPR globally (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.15,\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Native T1\u2010 and T2\u2010mapping during adenosine stress, although correlated with quantitative myocardial perfusion, are not alone sufficiently sensitive methods for distinguishing patients with MINOCA and reduced stress perfusion from healthy volunteers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.70070","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:20:01Z","timestamp":1780644001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stress native mapping does not distinguish patients with previous myocardial infarction with non\u2010obstructive coronary arteries from healthy volunteers"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5009-6244","authenticated-orcid":false,"given":"Daniel F.","family":"Andersson","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Karolinska Institutet and Karolinska University Hospital Stockholm 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