{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:04:26Z","timestamp":1785305066972,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There are few reliable predictors for reduced pain after biliary sphincterotomy or medical therapy in patients with sphincter of Oddi dysfunction (SOD). We explored whether prolonged intestinal bile excretion time, dilated common bile duct (CBD) diameter, or elevated alanine aminotransferase (ALT) were associated with reduced pain after treatment for SOD. This is a retrospective, single\u2010centre study. Consecutive patients suspected of SOD were identified and screened. Medical treatment for SOD followed institutional standards in line with the Regional pain medication guidelines. The primary outcome was potential prognostic markers for reduced pain. In the biliary sphincterotomy group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200934), 85% patients experienced reduced pain when evaluated in the outpatient clinic, while 60% of patients receiving medical therapy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009159) experienced reduced pain (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009). No association was found between the hepatobiliary scintigraphy excretion time nor ALT and reduced pain in either treatment group. However, a dilated CBD was associated with reduced pain (odds ratio 2.89; 95% CI [1.02;8.17]). In SOD patients, amelioration of pain in both medically and surgically treated patients is primarily associated with common bile duct dilation, rather than hepatobiliary scintigraphy excretion time or ALT.\n                  <\/jats:p>","DOI":"10.1111\/cpf.70074","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:46:18Z","timestamp":1780897578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In sphincter of Oddi patients, amelioration of pain is primarily associated with common bile duct dilation rather than hepatobiliary scintigraphy excretion time or alanine amino transferase \u2013 a single centre, retrospective study"],"prefix":"10.1111","volume":"46","author":[{"given":"Marina","family":"Kegn\u00e6s","sequence":"first","affiliation":[{"name":"Pancreatitis Centre East, Gastro Unit, Copenhagen University Hospital \u2010 Amager and Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M\u00f8nsted","family":"Shabanzadeh","sequence":"additional","affiliation":[{"name":"Department of Surgery Copenhagen University Hospital \u2013 North Zealand Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G\u00e1sdal","family":"Karstensen","sequence":"additional","affiliation":[{"name":"Pancreatitis Centre East, Gastro Unit, Copenhagen University Hospital \u2010 Amager and Hvidovre Hvidovre Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"N\u00f8jgaard","sequence":"additional","affiliation":[{"name":"Pancreatitis Centre East, Gastro Unit, Copenhagen University Hospital \u2010 Amager and Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-1072","authenticated-orcid":false,"given":"Mikkel","family":"Werge","sequence":"additional","affiliation":[{"name":"Pancreatitis Centre East, Gastro Unit, Copenhagen University Hospital \u2010 Amager and Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Centre of Functional Imaging and Research, Department of Clinical Physiology and Nuclear Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-4468","authenticated-orcid":false,"given":"Lise Lotte","family":"Gluud","sequence":"additional","affiliation":[{"name":"Pancreatitis Centre East, Gastro Unit, Copenhagen University Hospital \u2010 Amager and Hvidovre Hvidovre Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdan","family":"Novovic","sequence":"additional","affiliation":[{"name":"Pancreatitis Centre East, Gastro Unit, Copenhagen University Hospital \u2010 Amager and Hvidovre Hvidovre Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01279.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040225"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2445-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.9.1301"},{"key":"e_1_2_8_6_1","unstructured":"Catalano M.F.&Thosani N.C.(2025) Grover Shilpa Clinical Manifestations and Diagnosis of Sphincter of Oddi Dysfunction (D. 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UpToDate (2021) last visit November 10th;2025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90289-W"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2018.11.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088136"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.67"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332686"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5220"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.033"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.04.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901123200203"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1018172"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4278373"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-023-10539-3"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.118946"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02971.x"},{"issue":"6","key":"e_1_2_8_22_1","first-page":"1216","article-title":"A noninvasive test of sphincter of Oddi dysfunction in postcholecystectomy patients: the scintigraphic score","volume":"33","author":"Sostre S.","year":"1992","journal-title":"Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.6.838"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.1.98"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2021.00167"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i19.5755"},{"key":"e_1_2_8_27_1","first-page":"249","article-title":"Hepatobiliary scintigraphy in 2014","volume":"42","author":"Ziessman H.A.","year":"2014","journal-title":"Journal of Nuclear Medicine Technology"}],"container-title":["Clinical Physiology and Functional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.70074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cpf.70074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpf.70074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:48:46Z","timestamp":1785304126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpf.70074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,7]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/cpf.70074"],"URL":"https:\/\/doi.org\/10.1111\/cpf.70074","archive":["Portico"],"relation":{},"ISSN":["1475-0961","1475-097X"],"issn-type":[{"value":"1475-0961","type":"print"},{"value":"1475-097X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,7]]},"assertion":[{"value":"2025-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70074"}}