{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:04:22Z","timestamp":1785305062493,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["025\u201002218"],"award-info":[{"award-number":["025\u201002218"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","award":["2024\u2010YF0044"],"award-info":[{"award-number":["2024\u2010YF0044"]}],"id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021728","name":"Stiftelsen Bundy Academy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004817","name":"Lund University Medical Faculty Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical monitoring of patients with heart failure or cardiomyopathy is facilitated by detailed assessment of cardiac loading conditions. Specifically, alterations in preload and afterload may unmask pathology through effects on ventricular pressure\u2013volume (PV) relations. Therefore, the aim was to assess non\u2010invasive PV loops during left ventricular load manipulation in healthy participants and in patients with hypertrophic cardiomyopathy (HCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In total,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946 participants were studied in paired experiments at baseline and during load manipulation. Controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) and patients with HCM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) were assessed at baseline and during intravenous infusion of 1.5\u20132\u2009L isotonic saline, and another group of volunteers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098) was assessed at baseline and during infusion of glyceryl trinitrate (GTN). Non\u2010invasive PV loops were calculated from cardiovascular magnetic resonance (CMR) and concurrent brachial blood\u2010pressure measurements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Saline infusion brought about increased end\u2010diastolic and decreased end\u2010systolic volumes in controls, but not in HCM. Concurrently, PV loops revealed mechanistic differences, where controls but not HCM exhibited decreased arterial elastance and potential energy during load manipulation. In both groups, ventricular\u2010arterial coupling (VAC) decreased, and ventricular efficiency and cardiac output increased. Infusion of GTN resulted in decreased ventricular volumes. Contrary to saline infusion, volunteers receiving GTN retained unchanged arterial elastance, VAC, ventricular efficiency and cardiac output.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non\u2010invasive PV analysis from CMR detects cardiac response to altered loading conditions in healthy participants and in patients with HCM. Our findings support the use of CMR\u2010derived PV loops for detailed assessment of cardiac thermodynamic performance in relation to interventions affecting preload and afterload.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.70081","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:17:34Z","timestamp":1783941454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010invasive pressure\u2013volume loop analysis in left ventricular load manipulation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0710-3710","authenticated-orcid":false,"given":"Karin","family":"Pola","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund, Clinical Physiology Sk\u00e5ne University Hospital Lund, Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Burup Kristensen","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Clinical Sciences, Lund Lund University Lund Sweden"},{"name":"Department of Cardiology, The Heart Center Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Watson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Cambridge Cambridge UK"},{"name":"Oxford Centre for Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peregrine G.","family":"Green","sequence":"additional","affiliation":[{"name":"Oxford Centre for Magnetic Resonance Research University of Oxford Oxford UK"},{"name":"Department of Physiology, Anatomy and Genetics University of Oxford Oxford 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University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"M\u00f8gelvang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Center Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-3562","authenticated-orcid":false,"given":"Per M.","family":"Arvidsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund, Clinical Physiology Sk\u00e5ne University Hospital Lund, Lund University Lund 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