{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:04:22Z","timestamp":1785305062510,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","award":["ALF 444011"],"award-info":[{"award-number":["ALF 444011"]}],"id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart transplant (HTx) patients are known to be at risk of coronary microvascular dysfunction as well as having decreased exercise capacity. The aim of this study was to investigate if microvascular function in HTx patients differs from healthy controls and is related to objective measures of exercise capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010nine HTx patients (51\u2009\u00b1\u200915 years, 34% women) and 26 healthy controls (57\u2009\u00b1\u200910 years, 38% women) underwent CMR. Quantitative myocardial perfusion maps were acquired using single\u2010bolus (0.05\u2009mmol\/kg), dual\u2010sequence perfusion mapping at adenosine stress and at rest. In addition, all HTx patients performed a maximal cardiopulmonary exercise test with gas\u2010exchange analysis for objective assessment of exercise capacity. Heart transplant patients had lower stress myocardial perfusion (2.9\u2009\u00b1\u20090.8 vs 3.4\u2009\u00b1\u20090.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and lower myocardial perfusion reserve (MPR) (2.7\u2009\u00b1\u20090.7 vs 3.8\u2009\u00b1\u20091.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to healthy controls. Furthermore, MPR in HTx patients was correlated with maximal workload (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), O\n                      <jats:sub>2<\/jats:sub>\n                      pulse (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), peak O\n                      <jats:sub>2<\/jats:sub>\n                      consumption (VO\n                      <jats:sub>2<\/jats:sub>\n                      peak) (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and O\n                      <jats:sub>2<\/jats:sub>\n                      consumption (VO\n                      <jats:sub>2<\/jats:sub>\n                      ) at the anaerobic threshold (AT) (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Microvascular function as assessed by quantitative CMR perfusion mapping is lower in HTx patients than in healthy controls and is partly related to objective measures of exercise capacity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.70082","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:51:45Z","timestamp":1784213505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myocardial perfusion reserve is low in heart transplant patients and is related to exercise capacity"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3678-4074","authenticated-orcid":false,"given":"Kristian","family":"Dimovski","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grunde","family":"Gjesdal","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Steding\u2010Ehrenborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jablonowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xue","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kellman","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Braun","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Arheden","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Engblom","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund 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