{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:04:26Z","timestamp":1785305066981,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of 12\u2010week Mavacamten on left ventricular function in obstructive hypertrophic cardiomyopathy (oHCM) using myocardial work analysis, and explore its role in myocardial energy metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010five oHCM patients and 35 matched healthy controls were enroled. Patients received Mavacamten for 12 weeks. At baseline and post\u2010treatment, we measured LVOT gradient, LVEF, GLS, myocardial work parameters [GWI, GCW, GWW, GWE], mitral regurgitation severity, and SAM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Myocardial work parameters showed good reproducibility (ICCs\u2009&gt;\u20090.75). After 12 weeks, resting and provoked LVOT gradients significantly decreased (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Proportions of moderate\/severe mitral regurgitation and SAM reduced. GWI, GCW, and GWW decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while GWE increased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). NT\u2010proBNP decreased and NYHA functional class improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). LVEF, GLS, and left atrial diameter showed no significant changes. Compared with controls, baseline oHCM patients had lower GWI, GCW, GWE and higher GWW (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After treatment, GWE remained lower than controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and GWW remained higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Twelve\u2010week Mavacamten reduces LVOT obstruction in oHCM, accompanied by decreased GWI and increased GWE, while preserving systolic function and improving symptoms. Myocardial work parameters may serve as novel non\u2010invasive references for treatment evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpf.70084","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:20:53Z","timestamp":1785144053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the effect of mavacamten on left ventricular function in obstructive hypertrophic cardiomyopathy using myocardial work"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8913-5599","authenticated-orcid":false,"given":"Linlin","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing Medical University Nanjing China"},{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing University of Chinese Medicine Nanjing China"},{"name":"Department of Echocardiography Nanjing First Hospital, China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing Medical University Nanjing China"},{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing University of Chinese Medicine Nanjing China"},{"name":"Department of Echocardiography Nanjing First Hospital, China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1002-7271","authenticated-orcid":false,"given":"Ziwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing Medical University Nanjing China"},{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing University of Chinese Medicine Nanjing China"},{"name":"Department of Echocardiography Nanjing First Hospital, China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing Medical University Nanjing China"},{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing University of Chinese Medicine Nanjing China"},{"name":"Department of Echocardiography Nanjing First Hospital, China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenJuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing Medical University Nanjing China"},{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing University of Chinese Medicine Nanjing China"},{"name":"Department of Echocardiography Nanjing First Hospital, China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing Medical University Nanjing China"},{"name":"Department of Echocardiography, Nanjing First Hospital Nanjing University of Chinese Medicine Nanjing China"},{"name":"Department of Echocardiography Nanjing First Hospital, China Pharmaceutical University Nanjing 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