{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:16:46Z","timestamp":1791289006418,"version":"4.3.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sequential and reciprocal epithelial\u2013mesenchymal interactions, essential throughout such aspects of tooth morphogenesis as patterning, size and number of teeth, involves a well\u2010ordered series of inductive and permissive signals that exert global control over cell proliferation, differentiation and organogenesis. In particular, growth factors, transcription factors and their corresponding receptors, as well as other soluble morphogens, make up a regulatory network at the molecular level that synergistically or antagonistically controls intra\u2010\/inter\u2010cellular signal transduction during odontogenesis. This review summarizes recent advances in the study of crucial signalling pathways, for example of BMPs, Wnt, Notch, Shh and FGF, with emphasis on the potential integrated signalling network responsible for tooth formation. Our work probes into the complexity of these inductive signalling pathways to promote the understanding of tooth regeneration. Additionally, our study provides further insights into therapeutic strategies for various dental abnormalities in patterning and number, such as tooth agenesis and supernumerary teeth.<\/jats:p>","DOI":"10.1111\/cpr.12051","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T10:21:05Z","timestamp":1376734865000},"page":"501-508","source":"Crossref","is-referenced-by-count":26,"title":["An inductive signalling network regulates mammalian tooth morphogenesis with implications for tooth regeneration"],"prefix":"10.1111","volume":"46","author":[{"given":"Z.","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu 610041 China"},{"name":"Department of Oral and Maxillofacial Surgery West China College of Stomatology Sichuan University Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103.Supplement.155"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290299"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.054668"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.07.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.05.014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002414"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.103"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.370"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0937635100"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510364487"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24047"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.07.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.09.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.06.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00167-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81631-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211179110"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20285"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.056358"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004092"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05766"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607289103"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.033803"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.08.021"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060196"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.10.006"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.049528"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00629.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00871.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.053"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509337899"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700312"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107167"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.8143"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21097"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004270050282"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.085084"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200103096"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.3658"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.015081"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.02.012"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.04.006"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.079558"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1035602"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.061341"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.09.009"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.056051"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021531"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2009.09.002"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.05.012"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.089599"},{"key":"e_1_2_6_53_1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1242\/dev.129.6.1533","article-title":"FGF10 maintains stem cell compartment in developing mouse incisors","volume":"129","author":"Harada H","year":"2002","journal-title":"Development"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1086\/386293"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2010.01488.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308201214"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.02.012"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510365662"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.11.007"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401206"}],"container-title":["Cell Proliferation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcpr.12051","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.12051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:37:08Z","timestamp":1696250228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.12051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,17]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/cpr.12051"],"URL":"https:\/\/doi.org\/10.1111\/cpr.12051","archive":["Portico"],"relation":{},"ISSN":["0960-7722","1365-2184"],"issn-type":[{"value":"0960-7722","type":"print"},{"value":"1365-2184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,17]]}}}