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The number of studies documenting miRNA expression patterns in malignancy continues to expand rapidly, with continuously gained critical information regarding how aberrantly expressed miRNAs may contribute to carcinogenesis. miRNAs can influence cancer pathogenesis, playing a potential role as either oncogenes or tumour suppressors. Recently, several miRNAs have been reported to exert different regulatory functions in oesophageal cancer \u2013 the carcinoma typically arising from the epithelial lining of the oesophagus. These miRNAs also have potential clinical applications towards developing biomarkers or targets for possible use in diagnosis or therapy in oesophageal cancer. In this review, we have summarized the two (oncogenic or tumour suppressive) roles of miRNAs here, and their applications as potential biomarkers or therapeutic targets, which may illuminate future treatment for oesophageal cancer.<\/jats:p>","DOI":"10.1111\/cpr.12109","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T15:02:44Z","timestamp":1402066964000},"page":"277-286","source":"Crossref","is-referenced-by-count":66,"title":["MicroRNAs as oncogenes or tumour suppressors in oesophageal cancer: potential biomarkers and therapeutic targets"],"prefix":"10.1111","volume":"47","author":[{"given":"J.","family":"Huang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences Sichuan University Chengdu 610064 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010M.","family":"Gao","sequence":"additional","affiliation":[{"name":"The First Attached Hospital of Hebei Northern Institute Zhangjiakou 075000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010F.","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Attached Hospital of Hebei Northern Institute Zhangjiakou 075000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010B.","family":"Liu","sequence":"additional","affiliation":[{"name":"General Hospital of Armed Police Forces Beijing 100039 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.\u2010G.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Hepatobiliary Surgery Department of Baotou Tumour Hospital BaoTou Inner Mongolia Autonomous Region 014000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Medical Center of Du Jiang Yan Chengdu 611830 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bse0540017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2011.04.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1167"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100209"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2296"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242606799"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth717"},{"key":"e_1_2_9_11_1","first-page":"1292","article-title":"MicroRNA in the pathogenesis and prognosis of esophageal cancer","volume":"19","author":"Gu J","year":"2013","journal-title":"Curr. 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