{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:21:23Z","timestamp":1770747683712,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Textiles used to make clothing can represent a source, often ignored, of chemicals potentially noxious to both skin and the whole organism. Among the most frequently produced potentially noxious chemical manufacturing by\u2010products are formaldehyde (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>), nickel (Ni) and hexavalent chromium (Cr); they are of potential clinical interest as all are known to be carcinogenic to humans and to be potent skin sensitizers. The aim of this study was to investigate,<jats:italic>in vitro<\/jats:italic>, effects of these potentially dangerous compounds on two different melanoma cell lines. In particular, attention was focused on A375P, a poorly metastatic and low invasive cell line and<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MEL<\/jats:styled-content>\u201028, a highly metastatic cell line.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Effects of these compounds was evaluated on A375P and<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MEL<\/jats:styled-content>\u201028 cells.<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>(1\u20135\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc>), Ni<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>(10<jats:sup>\u22126<\/jats:sup>\u201310<jats:sup>\u22123<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc>), K<jats:sub>2<\/jats:sub>Cr<jats:sub>2<\/jats:sub>O<jats:sub>7<\/jats:sub>(10<jats:sup>\u22127<\/jats:sup>\u201310<jats:sup>\u22126<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc>) effects on cell proliferation were evaluated by cell counting, while<jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>pathway involvement was evaluated by Western blot analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low concentrations of the chemicals, covering a range that corresponds to commonly accepted limits in textile production, induced a significant increase in cell proliferation concomitant with transient activation of phosphorylated<jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Data obtained suggest that increasing attention must be focused on these by\u2010products' potentially harmful effects in chemical manufacturing of clothes and accessories, that remain for long periods of time, in contact with human skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12132","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T09:44:04Z","timestamp":1410860644000},"page":"578-586","source":"Crossref","is-referenced-by-count":19,"title":["Textile industry manufacturing by\u2010products induce human melanoma cell proliferation<i>via<\/i><scp>ERK<\/scp>1\/2 activation"],"prefix":"10.1111","volume":"47","author":[{"given":"M.","family":"Rizzi","sequence":"first","affiliation":[{"name":"Innovative Research Laboratory on Wound Healing Health Sciences Department University of Eastern Piedmont Novara 28100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cravello","sequence":"additional","affiliation":[{"name":"Associazione Tessile e Salute (Health and Textile Association) Biella 13900 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