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Natural tendon\u2013bone healing usually results in fibrous scar tissue, which is of inferior quality compared to native attachment. In addition, the early formed fibrous attachment after surgery is often not reliable to support functional rehabilitation, which may lead to graft failure or unsatisfied function of the knee joint. Thus, strategies to promote tendon\u2013bone healing are crucial for prompt and satisfactory functional recovery. Recently, a variety of biological approaches, including active substances, gene transfer, tissue engineering and stem cells, have been proposed and applied to enhance tendon\u2013bone healing. Among these, stem cell therapy has been shown to have promising prospects and draws increasing attention. From commonly investigated bone marrow\u2010derived mesenchymal stem cells (\n                    <jats:styled-content style=\"fixed-case\">bMSC<\/jats:styled-content>\n                    s) to emerging\n                    <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content>\n                    \u2010derived\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    34+ stem cells, multiple stem cell types have been proven to be effective in accelerating tendon\u2013bone healing. This review describes the current understanding of tendon\u2013bone healing and summarizes the current status of related stem cell therapy. Future limitations and perspectives are also discussed.\n                  <\/jats:p>","DOI":"10.1111\/cpr.12242","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T02:12:14Z","timestamp":1456798334000},"page":"154-162","source":"Crossref","is-referenced-by-count":75,"title":["Stem cell therapy: a promising biological strategy for tendon\u2013bone healing after anterior cruciate ligament reconstruction"],"prefix":"10.1111","volume":"49","author":[{"given":"Zi\u2010Chen","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Zhongda Hospital Medical School of Southeast University Nanjing 210009 China"},{"name":"Surgical Research Center Medical School of Southeast University Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804745"},{"key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00003086-199010000-00027","article-title":"The outcome of nonoperatively treated complete tears of the anterior cruciate ligament in active young adults","volume":"259","author":"Barrack RL","year":"1990","journal-title":"Clin. 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