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This tumour lacks systemic manifestations and prognosis of patients with <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content> remains poor despite recent advancement of chemoradiotherapy. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s are small non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that post\u2010transcriptionally downregulate gene expression by binding to target <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s, inducing their degradation or translational repression. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s play significant roles in almost all malignancy\u2010related biological processes, including cell proliferation, differentiation, apoptosis and metabolism. Many deregulated mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s has been identified in <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content> but their biological significance remains to be fully elucidated. In this review, we summarize current evidence regarding the pathogenic role of <jats:styled-content style=\"fixed-case\">PCNSL<\/jats:styled-content>\u2010associated micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s and their potential applications for diagnosis and prognostication of this deadly disease.<\/jats:p>","DOI":"10.1111\/cpr.12243","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T01:53:26Z","timestamp":1458352406000},"page":"147-153","source":"Crossref","is-referenced-by-count":15,"title":["Role of micro<scp>RNA<\/scp>s in primary central nervous system lymphomas"],"prefix":"10.1111","volume":"49","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing 100042 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