{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:30:04Z","timestamp":1768721404977,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402496"],"award-info":[{"award-number":["81402496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473091"],"award-info":[{"award-number":["81473091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260628"],"award-info":[{"award-number":["81260628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>MicroRNAs (miRNAs) are endogenous ~23 nucleotides (nt) RNAs, regulating gene expression by pairing to the mRNAs of protein\u2010coding genes to direct their post\u2010transcriptional repression. Both in normal and aberrant activities, miRNAs contribute to a recurring paradigm of cellular behaviors in pathological settings, especially in gerontology. Autophagy, a multi\u2010step lysosomal degradation process with function to degrade long\u2010lived proteins and damaged organelles, has significant impact on gerontology. Thus, elucidating how miRNAs participate in autophagy may enlarge the scope of miRNA in autophagy and facilitate researches in gerontology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Herein, based upon the published studies, predicted targets and gerontology\u2010related diseases, we constructed a web resource named Gerontology\u2010Autophagic\u2010MicroRNA Database (GAMDB) (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/gamdb.liu-lab.com\/index.php\">http:\/\/gamdb.liu-lab.com\/index.php<\/jats:ext-link>), which contained 836 autophagy\u2010related miRNAs, 197 targeted genes\/proteins and 56 aging\u2010related diseases such as Parkinson' disease, Alzheimer's disease and Huntington's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>We made use of large amounts of data to elucidate the intricate relationships between microRNA\u2010regulated autophagic mechanisms and gerontology. This database will facilitate better understanding of autophagy regulation network in gerontology and thus promoting gerontology\u2010related therapy in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12247","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T17:14:30Z","timestamp":1459617270000},"page":"246-251","source":"Crossref","is-referenced-by-count":12,"title":["<scp>GAMDB<\/scp>: a web resource to connect microRNAs with autophagy in gerontology"],"prefix":"10.1111","volume":"49","author":[{"given":"Lan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center of Biotherapy Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center of Biotherapy Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center of Biotherapy Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center of Biotherapy Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sicheng","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center of Biotherapy Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ouyang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center of Biotherapy Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University, and Collaborative Innovation Center of Biotherapy Chengdu 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyang","family":"Cai","sequence":"additional","affiliation":[{"name":"Center of Growth, Metabolism, and Aging Key Laboratory of Bio\u2010Resources and Eco\u2010Environment College of Life Sciences Sichuan University Chengdu 610064 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