{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:00:38Z","timestamp":1778569238238,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401847"],"award-info":[{"award-number":["81401847"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neural stem cells (<jats:styled-content style=\"fixed-case\">NSC<\/jats:styled-content>s) are immature precursors of the central nervous system (CNS), with self\u2010renewal and multipotential differentiation abilities. Their proliferation and differentiation are dynamically regulated by hormonal and local factors. Alteration in neurogenesis is associated with many neurological disorders. Increasing evidence suggests that modulation of <jats:styled-content style=\"fixed-case\">NSC<\/jats:styled-content>s can be a promising therapeutic approach for neural injury and neurodegenerative disorders. Melatonin, a pineal gland\u2010derived hormone, regulates the neuroimmuno\u2010endocrine axis and is functionally important to the circadian rhythm, tumour suppression and immunity. In the CNS, melatonin exerts neuroprotective effects in many diseases, such as Parkinson's disease, Alzheimer's disease and ischaemic brain injury. Emerging evidence suggests that it might also mediate such protective action by influencing proliferation and differentiation of <jats:styled-content style=\"fixed-case\">NSC<\/jats:styled-content>s. In this article, we review the current literature concerned with effects of melatonin on <jats:styled-content style=\"fixed-case\">NSC<\/jats:styled-content>s in different physiological and pathological conditions.<\/jats:p>","DOI":"10.1111\/cpr.12323","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T08:01:41Z","timestamp":1481529701000},"source":"Crossref","is-referenced-by-count":55,"title":["Protective roles of melatonin in central nervous system diseases by regulation of neural stem cells"],"prefix":"10.1111","volume":"50","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.V.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Ka Kei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong China"},{"name":"State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong 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