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Meanwhile, future challenges, limitations and perspectives are also discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Search and analyze the related articles in pubmed database through the multi\u2010combination of keywords like \u201cstem cells\u201d,\u201dexosomes\u201d,\u201dbone regeneration\u201d and \u201cfracture healing\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Stem cell\u2010derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention. This strategy helps to promote proliferation and migration of cells, as well as osteogenesis and angiogenesis, in the process of bone formation. Although the exact mechanisms remain elusive, exosomal mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s seem to play vital roles. Future studies are required to solve multiple problems before clinical application, including comprehensive and thorough understanding of exosomes, the exact roles of exosomes in regulating bone formation, and the optimal source, dose and frequency of treatment, as well as technical and safety issues. Moreover, studies based on fracture models of large animals are could offer guidance and are in demand.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12359","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T11:06:48Z","timestamp":1500980808000},"source":"Crossref","is-referenced-by-count":91,"title":["Stem cell\u2010derived exosomes: A promising strategy for fracture healing"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-2460","authenticated-orcid":false,"given":"Zi\u2010Chen","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Emergency Changhai Hospital Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Zhongda Hospital Medical School of Southeast University  Nanjing 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