{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:29:06Z","timestamp":1768811346780,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Colorectal neoplasia differentially expressed (<jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content>), a vital cancer\u2010related long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (lncRNA), has been brought to reports for playing quintessential functions in the growth and progression of several human malignancies. Nevertheless, the expression as well as the functional mechanisms of <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> in pancreatic cancer is not known so for. This study aimed at investigating the biological and clinical importance of <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> in human pancreatic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The expression levels of <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> in pancreatic cancer tissues as well as cell lines were identified with the help of quantitative real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> (qRT\u2010PCR). Furthermore, the analysis of the relationship between <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> expression and clinicopathologic characteristics of patients with pancreatic cancer was also performed. Novel target of <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> was identified with the use of bioinformatics analysis and confirmed by a dual\u2010luciferase reporter assay. Colorectal neoplasia differentially expressed was knocked down using si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in pancreatic cancer cells. Thereafter, cell proliferation, migration and invasion were examined. Tumour xenograft was created to explore the function of <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> in tumorigenesis in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Upregulation of the expression of <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> was found in pancreatic cancer tissues as well as cell lines, in comparison with the adjacent non\u2010tumour tissues and human pancreatic duct epithelial cells. High expression of <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> was correlated with poor clinicpathological characteristics and shorter overall survival. We identified miR\u2010384 as a direct target for <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content>. Moreover, the <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> knockdown considerably inhibited pancreatic cancer cell proliferation, migration and invasion not only in vitro but also in vivo. In addition, <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> positively regulated <jats:styled-content style=\"fixed-case\">IRS<\/jats:styled-content>1 expression through sponging miR\u2010384.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Colorectal neoplasia differentially expressed performed an oncogenic function in cell proliferation as well as metastasis of pancreatic cancer. Our results suggest that <jats:styled-content style=\"fixed-case\">CRNDE<\/jats:styled-content> is likely to serve as an efficient therapeutic approach in respect of pancreatic cancer treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12389","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T04:52:43Z","timestamp":1506055963000},"source":"Crossref","is-referenced-by-count":78,"title":["RETRACTED: Long non\u2010coding <scp>RNA CRNDE<\/scp> sponges miR\u2010384 to promote proliferation and metastasis of pancreatic cancer cells through upregulating <scp>IRS<\/scp>1"],"prefix":"10.1111","volume":"50","author":[{"given":"Gang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biliary and Pancreatic Surgery Anhui Provincial Hospital Affiliated with Anhui Medical University  Hefei Anhui 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