{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:24:18Z","timestamp":1778081058067,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["2013ZYJB0102"],"award-info":[{"award-number":["2013ZYJB0102"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300625"],"award-info":[{"award-number":["81300625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400755"],"award-info":[{"award-number":["81400755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570682"],"award-info":[{"award-number":["81570682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Urinary tract infection, urinary frequency, urgency, urodynia and haemorrhage are common post\u2010operative complications of thulium laser resection of the prostate (Tm<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>). Our study mainly focuses on the role of finasteride in prostate wound healing through <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> signalling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Tm<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content> beagles were randomly distributed into different treatment groups. Serum and intra\u2010prostatic testosterone and <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> level were determined. Histological analysis was conducted to study the re\u2010epithelialization and inflammatory response of the prostatic urethra in each group. We investigated the role of androgen in proliferation and inflammatory response in prostate. In addition, the effects of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 on prostate epithelium and stromal cells were also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Testosterone and <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> level increased in testosterone group and <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> decreased in finasteride group. Accelerated wound healing of prostatic urethra was observed in the finasteride group. <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> suppressed proliferation of prostate epithelium and enhanced inflammatory response in prostate. We confirmed that <jats:styled-content style=\"fixed-case\">DHT<\/jats:styled-content> enhanced macrophages <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 secretion through <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> signalling. <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 suppressed proliferation of prostate epithelial cells and retarded cell migration. <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 also played a pivotal role in suppressing fibroblasts activation and contraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Testosterone treatment repressed re\u2010epithelialization and wound healing of prostatic urethra. Finasteride treatment may be an effective way to promote prostate re\u2010epithelialization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12415","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T02:56:38Z","timestamp":1512096998000},"source":"Crossref","is-referenced-by-count":17,"title":["Finasteride accelerates prostate wound healing after thulium laser resection through <scp>DHT<\/scp> and <scp>AR<\/scp> signalling"],"prefix":"10.1111","volume":"51","author":[{"given":"Ruizhe","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology Guizhou Provincial People's Hospital  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-3157","authenticated-orcid":false,"given":"Shujie","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bangmin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"S4","article-title":"Medical therapy for benign prostatic hyperplasia \u2013 Present and future impact","volume":"13","author":"Issa MM","year":"2007","journal-title":"Am J Manag Care"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.08.013"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Benign prostatic hyperplasia and male lower urinary tract symptoms (LUTS)","volume":"2011","author":"McNicholas T","year":"2011","journal-title":"BMJ Clin Evid"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000078083.38675.79"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06197.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06256.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4103\/1008-682X.146972","article-title":"Re\u2010epithelialization resulted from prostate basal cells in canine prostatic urethra may represent the ideal healing method after two\u2010micron laser resection of the prostate","volume":"17","author":"Cao Y","year":"2015","journal-title":"Asian J Androl"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-007-6115-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.12.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.03.110"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.15.6419"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22828"},{"key":"e_1_2_8_14_1","first-page":"103","article-title":"Collagen gel contraction assay","volume":"341","author":"Ngo P","year":"2006","journal-title":"Methods Mol Biol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-013-0411-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00309.2002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00209.2011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.09.016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.1.103"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700890"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215704"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39335"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2011.04.006"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1016\/S0021-9258(18)94513-8","article-title":"The intranuclear binding of testosterone and 5\u2010alpha\u2010androstan\u201017\u2010beta\u2010ol\u20103\u2010one by rat prostate","volume":"243","author":"Bruchovsky N","year":"1968","journal-title":"J Biol Chem"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2741\/2277"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1700287"},{"key":"e_1_2_8_27_1","first-page":"1","article-title":"Androgen induction of in vitro prostate cell differentiation","volume":"13","author":"Whitacre DC","year":"2002","journal-title":"Cell Growth Differ"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2938"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8756"},{"key":"e_1_2_8_30_1","first-page":"473","article-title":"Implication of cell kinetic changes during the progression of human prostatic cancer","volume":"1","author":"Berges RR","year":"1995","journal-title":"Clin Cancer Res"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704940104"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00017.2009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12827"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00451.2005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20368"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990240303"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65632-5"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.13.3.376"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.2741\/2692"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.3733"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2284"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111600109"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02786"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2003.11614.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2444"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120225"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.41"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01299-7"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23301"}],"container-title":["Cell Proliferation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcpr.12415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.12415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:27:56Z","timestamp":1695515276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.12415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,30]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/cpr.12415"],"URL":"https:\/\/doi.org\/10.1111\/cpr.12415","archive":["Portico"],"relation":{},"ISSN":["0960-7722","1365-2184"],"issn-type":[{"value":"0960-7722","type":"print"},{"value":"1365-2184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,30]]},"article-number":"e12415"}}