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Diagnosis and therapy of early lung tumour are still challenged.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The magnetic nanochains (\n NC<\/jats:styled-content>\n s) with biocompatibility and transverse relaxivity (r\n 2<\/jats:sub>\n \u00a0=\u00a0231 Fe mmol\u00a0l\n \u22121<\/jats:sup>\n \u00a0s\n \u22121<\/jats:sup>\n ) were fabricated through a co\u2010precipitation method in the assistance of dextran, and then, linked with chlorotoxin (\n CTX<\/jats:styled-content>\n ) and curcumin (Cur)\n via<\/jats:italic>\n the\n PEG<\/jats:styled-content>\n ylation and carbodiimide technique (named as\n CTX<\/jats:styled-content>\n \u2010\n NC<\/jats:styled-content>\n s\u2010Cur).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The results of cell test indicated that\n CTX<\/jats:styled-content>\n \u2010conjugated\n NC<\/jats:styled-content>\n s could obviously target non\u2013small\u2010cell lung cancer cells and limit their growth. The\n in vivo<\/jats:italic>\n results of magnetic resonance imaging and fluorescence imaging indicated that the\n CTX<\/jats:styled-content>\n \u2010\n NC<\/jats:styled-content>\n s\u2010Cur significantly targeted the tumour site and enhanced images contrast of the small\u2010size tumour. Moreover, the results of everyday tail\u2010vein injection confirmed that\n CTX<\/jats:styled-content>\n \u2010\n NC<\/jats:styled-content>\n s\u2010Cur could significantly limit the growth of early tumour, due to blocking Cl ion channels from\n CTX<\/jats:styled-content>\n \u2010\n NC<\/jats:styled-content>\n s\u2010Cur\u2010\n MMP<\/jats:styled-content>\n \u20102 composite and intracellular\n ROS<\/jats:styled-content>\n increase from Cur treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n We provided a mechanism about the effect of\n CTX<\/jats:styled-content>\n \u2010\n NC<\/jats:styled-content>\n s\u2010Cur on the targeting and limiting early tumour, and these results indicated the application foreground of\n CTX<\/jats:styled-content>\n \u2010\n NC<\/jats:styled-content>\n s\u2010Cur in tumour diagnosis and therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cpr.12486","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T12:29:48Z","timestamp":1534940988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fabrication of magnetic nanochains linked with\n CTX<\/scp>\n and curcumin for dual modal imaging detection and limitation of early tumour"],"prefix":"10.1111","volume":"51","author":[{"given":"Yuedi","family":"Yang","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9210-1842","authenticated-orcid":false,"given":"Zhongbing","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Sichuan University Chengdu 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