{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:47:34Z","timestamp":1792622854071,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772650"],"award-info":[{"award-number":["81772650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572302"],"award-info":[{"award-number":["81572302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81322037"],"award-info":[{"award-number":["81322037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81421003"],"award-info":[{"award-number":["81421003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730016"],"award-info":[{"award-number":["81730016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Chinese Herb QingBai decoction (QBD) has been approved affective in the treatment of IBD patients in clinic. However, the underlying mechanism remains unknown. We aim to investigate the effect of QBD on the mouse model of ulcerative colitis and its possible mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>C57\/bL mice were given 5% DSS to induce colitis and were divided as QBD and mesalazine group. Weight, faeces and mental status were recorded each day and the histopathological changes (goblet cells etc) of the colon were observed after sacrificed. Fluorescein isothiocyanate\u2010dextran 4000 was measured to reflect the intestinal mucosal permeability. In addition, cell junction\u2010related proteins and possible signal pathways were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>QingBai decoction could significantly alleviate the inflammation and the protection effect of colitis is comparable as those in mesalazine enema group. It was found that the permeability reduced significantly with QBD treatment vs the control group, while no significant difference between the mesalazine and QBD groups. QBD treatment could upregulate the expression of tight junction complex\uff08ZO\u20101, claudin\u20101 and occludin\uff09and muc\u20102 expression. It significantly reduced the production and secretion of serials proinflammatory cytokines (IL\u20101\u03b2, IL\u20106, Kc and TNF\u2010\u03b1) compared with the control group. Meanwhile, NF\u2010\u03baB and Notch pathways were regulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>QingBai decoction can effectively alleviate intestinal inflammation and mucosal barrier function in colitis mice, and the mechanism may be related to the inhibition of inflammatory cascade as well as enhanced mucus layer barrier and mechanical barrier function by NF\u2010\u03baB and Notch signalling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12547","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T10:53:11Z","timestamp":1547808791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["QingBai decoction regulates intestinal permeability of dextran sulphate sodium\u2010induced colitis through the modulation of notch and NF\u2010\u03baB signalling"],"prefix":"10.1111","volume":"52","author":[{"given":"Jun\u2010Chao","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Qiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Ningxia Medical University Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Ying","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology and Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzuo","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology and Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology and Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology and Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology and Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology and Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University Xi\u2019an China"},{"name":"Department of Gastroenterology NO. 307 Hospital of PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Ningxia Medical University Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Engineering, Faculty of Life Science Northwest University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology General Hospital of Ningxia Medical University Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaichun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology and Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-2448","authenticated-orcid":false,"given":"Jie","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology and Institute of Digestive Diseases Xijing Hospital, The Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.245"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"029","article-title":"Integrated traditional Chinese and western medicine in the treatment of 225 cases of ulcerative colitis 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