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This peculiar ability of SeC is dependent on secretion of a plethora of factors including maturation factors, hormones, growth factors, cytokines and immunomodulatory factors. The anti\u2010inflammatory and trophic properties of SeC have been largely exploited in several experimental models of diseases, diabetes being the most studied. Duchenne muscular dystrophy (DMD) is a lethal X\u2010linked recessive pathology in which lack of functional dystrophin leads to progressive muscle degeneration culminating in loss of locomotion and premature death. Despite a huge effort to find a cure, DMD patients are currently treated with anti\u2010inflammatory steroids. Recently, encapsulated porcine SeC (MC\u2010SeC) have been injected ip in the absence of immunosuppression in an animal model of DMD resulting in reduction of muscle inflammation and amelioration of muscle morphology and functionality, thus opening an additional avenue in the treatment of DMD. The novel protocol is endowed with the advantage of being potentially applicable to all the cohort of DMD patients regardless of the mutation. This mini\u2010review addresses several issues linked to the possible use of MC\u2010SeC injected ip in dystrophic people.<\/jats:p>","DOI":"10.1111\/cpr.12599","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T07:15:09Z","timestamp":1553584509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Do porcine Sertoli cells represent an opportunity for Duchenne muscular dystrophy?"],"prefix":"10.1111","volume":"52","author":[{"given":"Sara","family":"Chiappalupi","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"},{"name":"Interuniversity Institute of Myology (IIM) Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"},{"name":"Interuniversity 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