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There is extensive evidence that suggests many immune\u2010associated genes have essential roles in GBS. However, the associations between immune genes and GBS have not been sufficiently examined as most previous studies have only focused on individual genes rather than their entire interaction networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this study, multiple levels of data including immune\u2010associated genes, GBS\u2010associated genes, protein\u2010protein interaction (PPI) networks and gene expression profiles were integrated, and an immune or GBS\u2010directed neighbour co\u2010expressed network (IOGDNC network) and a GBS\u2010directed neighbour co\u2010expressed network (GDNC network) were constructed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analysis shows the immune\u2010associated genes are strongly related to GBS\u2010associated genes whether at the interaction level or gene expression level. Five immune\u2010associated modules were also identified which could distinguish between GBS and normal samples. In addition, functional analysis indicated that immune\u2010associated genes are essential in GBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, these results highlight a strong relationship between immune\u2010associated genes and GBS existed and provide a potential role for immune\u2010associated genes as novel diagnostic and therapeutic biomarkers for GBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12634","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T07:23:36Z","timestamp":1557991416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inferring immune\u2010associated signatures based on a co\u2010expression network in Guillain\u2010Barr\u00e9 syndrome"],"prefix":"10.1111","volume":"52","author":[{"given":"Xiaoming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrui","family":"Bo","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Harbin Medical 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