{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:30Z","timestamp":1787014050479,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 81800999"],"award-info":[{"award-number":["Grant No. 81800999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["Grant No. KJQN201800414"],"award-info":[{"award-number":["Grant No. KJQN201800414"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Interleukin (IL)\u201037 is a natural suppressor of innate inflammation. This study was conducted to explore the anti\u2010inflammatory effects of IL\u201037 in temporomandibular joint (TMJ) inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The expression of IL\u201037 in the TMJ was measured using ELISA and IHC. Human TMJ chondrocytes were treated with IL\u201037b and IL\u20101\u03b2, and inflammation\u2010related factors were detected. siRNA\u2010IL\u20101R8 was transfected into chondrocytes, and the affected pathways were detected. IL\u201037b was used in disc\u2010perforation\u2010induced TMJ inflammation in SD rats. Micro\u2010CT, IHC, real\u2010time PCR and histological staining were used to quantify the therapeutic effect of IL\u201037b.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IL\u201037 was expressed in the synovium and the disc of patients with osteoarthritis (OA) and in the articular cartilage of condylar fracture patients. IL\u201037 was highly expressed in synovial fluid of patients with synovitis than in those with OA and disc displacement and was closely related to visual analogue scale (VAS) score. In vitro, IL\u201037b suppressed the expression of pro\u2010inflammatory factors. In addition, IL\u201037b exerted anti\u2010inflammatory effects via IL\u20101R8 by inhibiting the p38, ERK, JNK and NF\u2010\u03baB activation, while silencing IL\u20101R8 led to inflammation and upregulation of these signals. In disc\u2010perforation\u2010induced TMJ inflammation in SD rats, IL\u201037b suppressed inflammation and inhibited osteoclast formation to protect against TMJ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL\u201037b may be a novel therapeutic agent for TMJ inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cpr.12692","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T10:18:18Z","timestamp":1569579498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["IL\u201037b alleviates inflammation in the temporomandibular joint cartilage via IL\u20101R8 pathway"],"prefix":"10.1111","volume":"52","author":[{"given":"Ping","family":"Luo","sequence":"first","affiliation":[{"name":"College of Stomatology Chongqing Medical University Chongqing 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