{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:16:21Z","timestamp":1790507781455,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170263"],"award-info":[{"award-number":["BK20170263"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Interleukin\u201034 (IL\u201034) is associated with hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). However, the role and associated mechanisms of IL\u201034 in HBV\u2010related HCC remain unclear. In this study, the expression, biological function and associated mechanisms of IL\u201034 in HBV\u2010related HCC cells were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IL\u201034 expression induced by HBV and HBV X (HBX) gene was measured in hepatoma cells. The role of CCAAT\/enhancer\u2010binding protein \u03b1 (CEBP\/\u03b1) in HBX\u2010induced IL\u201034 expression was examined. The signal pathways involved in the expression of CEBP\/\u03b1 and IL\u201034 induced by HBX were assessed. The role of IL\u201034 in the proliferation and migration of HCC cells, and related mechanisms were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dependent on HBX, HBV increased IL\u201034 expression in hepatoma cells, and HBX upregulated and interacted with CEBP\/\u03b1 to enhance the activity of IL\u201034 promoters. CEBP\/\u03b1 mediated by HBX was associated with the activation of PI3\u2010K and NF\u2010\u03baB pathways to promote IL\u201034 expression. Via CSF1\u2010R and CD138, IL\u201034 promoted the proliferation and migration of hepatoma cells, and contributed to the activation of ERK and STAT3 pathways and the upregulation of Bcl\u2010xl and c\u2010Myc mediated by HBX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrate that IL\u201034 contributes to HBX\u2010mediated functional abnormality of HCC cells and provides a novel insight into the molecular mechanism of carcinogenesis mediated by HBX.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12703","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T03:35:07Z","timestamp":1571283307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Interleukin\u201034 mediated by hepatitis B virus X protein via CCAAT\/enhancer\u2010binding protein \u03b1 contributes to the proliferation and migration of hepatoma cells"],"prefix":"10.1111","volume":"52","author":[{"given":"Fanyun","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology and Immunology Jiangsu Key Laboratory of Immunity and Metabolism Xuzhou Medical University Xuzhou China"},{"name":"National Demonstration Center for Experimental Basic Medical Sciences Education Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology Jiangsu Key Laboratory of Immunity and Metabolism Xuzhou Medical University Xuzhou China"},{"name":"Clinical Laboratory Enze Hospital Taizhou Enze Medical Center Luqiao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology Jiangsu Key Laboratory of Immunity and Metabolism Xuzhou Medical 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