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Although IDD was deemed to be a natural process that comes with ageing, a growing body of evidence suggested that both genetic and environmental factors could modify the development of IDD. In this connection, aberrant function of nucleus pulposus cells has been implicated in IDD pathogenesis. Circular RNAs are a novel class of endogenous non\u2010coding RNAs that play crucial regulatory roles in diverse cellular processes. Recently, deregulation of circRNAs in nucleus pulposus cells was found to functionally participate in IDD development. In this review, we summarize the current knowledge regarding the deregulation of circRNAs in IDD in relation to their actions on nucleus pulposus cell functions, including cell proliferation, apoptosis and extracellular matrix synthesis\/degradation. The potential clinical utilities of circRNAs as therapeutic targets for the management of IDD are also discussed.<\/jats:p>","DOI":"10.1111\/cpr.12704","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T03:18:51Z","timestamp":1571282331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-0194","authenticated-orcid":false,"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-9796","authenticated-orcid":false,"given":"Shugang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T. 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