{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:01:18Z","timestamp":1789513278354,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991504"],"award-info":[{"award-number":["81991504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870768"],"award-info":[{"award-number":["81870768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570937"],"award-info":[{"award-number":["81570937"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study is to investigate the role of sensory nerve in tooth homeostasis and its effect on mesenchymal stromal\/stem cells (MSCs) in dental pulp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We established the rat denervated incisor models to identify the morphological and histological changes of tooth. The groups were as follows: IANx (inferior alveolar nerve section), SCGx (superior cervical ganglion removal), IANx\u00a0+\u00a0SCGx and Sham group. The biological behaviour of dental pulp stromal\/stem cells (DPSCs) was evaluated. Finally, we applied activin B to DPSCs from sensory nerve\u2010deficient microenvironment to analyse the changes of proliferation and apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incisor of IANx and IANx\u00a0+\u00a0SCGx groups exhibited obvious disorganized tooth structure, while SCGx group only showed slight decrease of dentin thickness, implying sensory nerve, not sympathetic nerve, contributes to the tooth homeostasis. Moreover, we found sensory nerve injury led to disfunction of DPSCs via activin B\/SMAD2\/3 signalling in vitro. Supplementing activin B promoted proliferation and reduced apoptosis of DPSCs in sensory nerve\u2010deficient microenvironment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This research first demonstrates that sensory nerve\u2010deficient microenvironment impairs tooth haemostasis by inducing apoptosis of DPSCs via activin B\/SMAD2\/3 signalling. Our study provides the evidence for the crucial role of sensory nerve in tooth homeostasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12803","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T07:26:25Z","timestamp":1585985185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Sensory nerve\u2010deficient microenvironment impairs tooth homeostasis by inducing apoptosis of dental pulp stem cells"],"prefix":"10.1111","volume":"53","author":[{"given":"An\u2010Qi","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"},{"name":"Department of Orthodontic Dentistry School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"},{"name":"Department of Orthodontic Dentistry School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Dong","family":"Fei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"},{"name":"Department of Periodontic Dentistry School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"},{"name":"Department of Preventive Dentistry School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"},{"name":"Department of Preventive Dentistry School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ning","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-2248","authenticated-orcid":false,"given":"Bei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi International Joint Research Center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University Xi'an China"},{"name":"Xi'an Institute of Tissue Engineering and Regenerative Medicine Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.053"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2010.01239.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066863"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345770560071901"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.01.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.12.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.08.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.02.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.002"},{"issue":"2757","key":"e_1_2_9_11_1","first-page":"e2755","article-title":"Skeletal stem cell\u2010schwann cell circuitry in mandibular repair","volume":"28","author":"Jones RE","year":"2019","journal-title":"Cell Rep"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.05.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf3227"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00103"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00029"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-016-0306-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345690480056701"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.07.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.09.139"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2016.09.027"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05762-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2077"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518758244"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15990"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2016.1216746"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20586"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345770560072001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216039"},{"key":"e_1_2_9_30_1","first-page":"1218","article-title":"Relationship between oxidative stress and \"burning mouth syndrome\" in female patients: a scientific hypothesis","volume":"16","author":"Tatullo M","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2016.03.086"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.038"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041016"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.10.046"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12501"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13536"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13498"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23643"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09262"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1085-9"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37819-6"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022194"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.16.2636"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2017.04.004"}],"container-title":["Cell Proliferation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcpr.12803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.12803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cpr.12803","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cpr.12803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:23:34Z","timestamp":1693970614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.12803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,4]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/cpr.12803"],"URL":"https:\/\/doi.org\/10.1111\/cpr.12803","archive":["Portico"],"relation":{},"ISSN":["0960-7722","1365-2184"],"issn-type":[{"value":"0960-7722","type":"print"},{"value":"1365-2184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,4]]},"assertion":[{"value":"2020-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12803"}}