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Propofol, one of the most widely used intravenous anaesthetics in surgery, was found to be involved in many cancer\u2010related pathophysiology processes, mainly including anti\u2010tumour and minor cancer\u2010promoting effects in various types of cancer. An increasing number of studies have identified that propofol plays a role in cancer by regulating the expression of multiple signalling pathways, downstream molecules, microRNAs and long non\u2010coding RNAs. Emerging evidence has indicated that propofol can enhance the anti\u2010tumour effect of chemotherapeutic drugs or some small molecular compounds. Additionally, in vivo animal models have shown that propofol inhibits tumour growth and metastasis. Furthermore, most clinical trials indicate that propofol is associated with better survival outcomes in cancer patients after surgery. Propofol use is encouraged in cancers that appear to have a better prognosis after its use during surgery. We hope that future large and prospective multicenter studies will provide more precise answers to guide the choice of anaesthetics during cancer surgery.<\/jats:p>","DOI":"10.1111\/cpr.12867","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T08:51:05Z","timestamp":1593420665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Effects of propofol on the development of cancer in humans"],"prefix":"10.1111","volume":"53","author":[{"given":"Yichi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou 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