{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:52:15Z","timestamp":1789055535563,"version":"build-2803163510"},"reference-count":75,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Human\u2010induced pluripotent stem cells (hiPSCs) are a promising cell source for treating ischaemic stroke. Although autologous hiPSCs provide the advantage of avoiding immune rejection, their practical limitations, such as substantial amount of time and costs to generate individual iPSC lines, have hampered their widespread application in clinical settings. In this study, we investigated the therapeutic potential of neural precursor cells derived from human HLA\u2010homozygous induced pluripotent stem cells (hiPSC\u2010NPCs) following intracerebral transplantation into a rodent model of middle cerebral artery occlusion (MCAo).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We differentiated a GMP\u2010grade HLA\u2010homozygous hiPSC line (CMC\u2010hiPSC\u2010004) into neural precursor cells for transplantation into rats at the subacute stage of ischaemic stroke (ie at 7\u00a0days after the induction of MCAo). To investigate functional recovery, the transplanted animals were subjected to five behavioural tests, namely the rotarod, stepping, mNSS, staircase and apomorphine\u2010induced rotation tests, for up to 12\u00a0weeks, followed by histological analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed that the hiPSC\u2010NPC transplantation produced significant behavioural improvements. At 12\u00a0weeks post\u2010transplantation, a high proportion of transplanted cells survived and had differentiated into MAP2<jats:sup>+<\/jats:sup> mature neurons, GABAergic neurons and DARPP32<jats:sup>+<\/jats:sup> medium spiny neurons. The transplanted cells formed neuronal connections with striatal neurons in the host brain. In addition, hiPSC\u2010NPC transplantation gave rise to enhanced endogenous repair processes, including decreases of post\u2010stroke neuroinflammation and glial scar formation and an increase of proliferating endogenous neural stem cells in the subventricular zone as well as the perilesional capillary networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results strongly suggest that HLA\u2010homozygous hiPSC\u2010NPCs may be useful for treating ischaemic stroke patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12884","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T08:16:01Z","timestamp":1595751361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Intracerebral transplantation of HLA\u2010homozygous human iPSC\u2010derived neural precursors ameliorates the behavioural and pathological deficits in a rodent model of ischaemic stroke"],"prefix":"10.1111","volume":"53","author":[{"given":"Jeong\u2010Eun","family":"Noh","sequence":"first","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Hun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology CHA Bundang Medical Center CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soohyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyeon","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul St. Mary\u2019s Hospital Institute of Medical Science The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology CHA Bundang Medical Center CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine CHA Bundang Medical Center CHA University Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6597-8208","authenticated-orcid":false,"given":"Jihwan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science CHA Stem Cell Institute CHA University Seongnam\u2010si Korea"},{"name":"iPS Bio, Inc. 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