{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:37:24Z","timestamp":1785548244512,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M660791"],"award-info":[{"award-number":["2019M660791"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31621004"],"award-info":[{"award-number":["31621004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Enormous progress has been made in cardiac regeneration using human embryonic stem cell\u2010derived cardiomyocyte (hESC\u2010CM) grafts in pre\u2010clinical trials. However, the rate of cell survival has remained very low due to anoikis after transplantation into the heart as single cells. Numerous solutions have been proposed to improve cell survival, and one of these strategies is to co\u2010transplant biocompatible materials or hydrogels with the hESC\u2010CMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In our study, we screened various combinations of biomaterials that could promote anoikis resistance and improve hESC\u2010CM survival upon co\u2010transplantation and promote cardiac functional recovery. We injected different combinations of Matrigel, alginate and hyaluronate with hESC\u2010CM suspensions into the myocardium of rat models with myocardial infarction (MI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that the group treated with a combination of hyaluronate and hESC\u2010CMs had the lowest arrhythmia rates when stimulated with programmed electrical stimulation. While all three combinations of hydrogel\u2010hESC\u2010CM treatments improved rat cardiac function compared with the saline control group, the combination with hyaluronate most significantly reduced pathological changes from left ventricular remodelling and improved both left ventricular function and left ventricular ejection fraction by 28\u00a0days post\u2010infarction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hence, we concluded that hyaluronate\u2010hESC\u2010CM is a superior combination therapy for promoting cardiac regeneration after myocardial infarction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12942","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T14:55:53Z","timestamp":1603810553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Hyaluronate supports hESC\u2010cardiomyocyte cell therapy for cardiac regeneration after acute 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