{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:50:37Z","timestamp":1775062237311,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["1191957202"],"award-info":[{"award-number":["1191957202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim was to investigate the prevalence and predictive variables of sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited participants from the Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass was quantified using bioimpedance, and muscle function was quantified using grip strength and gait speed. Logistic regression revealed the relationships between sarcopenia and nutritional, lifestyle, disease, psychosocial and physical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of sarcopenia and sarcopenic obesity was 9.2%\u201016.2% and 0.26%\u20109.1%, respectively. Old age, single status, undernourishment, higher income, smoking, low physical activity, poor appetite and low protein diets were significantly associated with sarcopenia. Multiple logistic regression analysis showed that age was a risk factor for all stages of sarcopenia, and participants above 80\u00a0years were greater than fivefold more susceptible to sarcopenia, while lower physical activity was an independent risk factor. The optimal cut\u2010off value for age was 71\u00a0years, which departs from the commonly accepted cut\u2010off of 60\u00a0years. Female participants were greater than twofold less susceptible to sarcopenia than male participants. The sterol derivative 25\u2010hydroxyvitamin D was associated with fourfold lower odds of sarcopenia in male participants. Several protein intake variables were also correlated with sarcopenia. Based on these parameters, we defined a highly predictive index for sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings support a predictive index of sarcopenia, which agglomerates the complex influences that sterol metabolism and nutrition exert on male vs female participants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.12989","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T03:47:56Z","timestamp":1613879276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian Chinese men and women"],"prefix":"10.1111","volume":"54","author":[{"given":"Chun\u2010Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Department of Health Medicine Peking Union Medical College Hospital Chinese Academy of Medical 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