{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:57:49Z","timestamp":1792166269553,"version":"4.4.0"},"reference-count":112,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874020"],"award-info":[{"award-number":["81874020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Proliferation"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Growth differentiation factor 5 (GDF\u20105) is essential for cartilage development and homeostasis. The expression and function of GDF\u20105 are highly associated with the pathogenesis of osteoarthritis (OA). OA, characterized by progressive degeneration of joint, particularly in cartilage, causes severe social burden. However, there is no effective approach to reverse the progression of this disease. Over the past decades, extensive studies have demonstrated the protective effects of GDF\u20105 against cartilage degeneration and defects. Here, we summarize the current literature describing the role of GDF\u20105 in development of cartilage and joints, and the association between the\n                    <jats:italic>GDF\u20105<\/jats:italic>\n                    gene polymorphisms and OA susceptibility. We also shed light on the protective effects of GDF\u20105 against OA in terms of direct GDF\u20105 supplementation and modulation of the GDF\u20105\u2010related signalling. Finally, we discuss the current limitations in the application of GDF\u20105 for the clinical treatment of OA. This review provides a comprehensive insight into the role of GDF\u20105 in cartilage and emphasizes GDF\u20105 as a potential therapeutic candidate in OA.\n                  <\/jats:p>","DOI":"10.1111\/cpr.12998","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T08:29:40Z","timestamp":1612168180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate"],"prefix":"10.1111","volume":"54","author":[{"given":"Kai","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Orthopedics Tongji Medical College Tongji Hospital Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Tongji Medical College Tongji Hospital 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