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Clinical use of glucocorticoids through submucosal injection is beneficial for inhibiting oesophageal stricture following injury; however, it also has limitations, such as dose loss and perforation. Hence, alternatives to glucocorticoid therapy should be developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A novel porous composite scaffold, ChCo\u2010TAMS, composed of chitosan, collagen\u2010I and triamcinolone acetonide (TA) loaded into poly (lactic\u2010co\u2010glycolic) acid (PLGA) microspheres (TAMS), was successfully constructed and subjected to biological testing to ameliorate oesophageal ESD\u2010related stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The synthesized biomaterials displayed unique properties in inhibiting the activation of macrophages, chemokine\u2010mediated cell recruitment and fibrogenesis of fibroblasts. Further application of the scaffolds in the rat dermal defect and porcine oesophageal ESD model showed that these novel scaffolds played a robust role in inhibiting wound contracture and oesophageal ESD strictures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The developed composite scaffolds provide a promising clinical medical device for the prevention of post\u2010operative oesophageal stricture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cpr.13004","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T03:05:11Z","timestamp":1612753511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Biological testing of chitosan\u2010collagen\u2010based porous scaffolds loaded with PLGA\/Triamcinolone microspheres for ameliorating endoscopic dissection\u2010related stenosis in oesophagus"],"prefix":"10.1111","volume":"54","author":[{"given":"Wenkai","family":"Ni","sequence":"first","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute Zhongshan Hospital Fudan University Shanghai China"},{"name":"Department of Gastroenterology Affiliated Hospital of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengli","family":"Lin","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiyan","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Nantong University Nantong China"},{"name":"Medical College Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingbing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Medicine Affiliated Hospital of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co\u2010innovation Center of Neuroregeneration Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co\u2010innovation Center of Neuroregeneration Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuihua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Medicine Affiliated Hospital of Nantong University Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-7190","authenticated-orcid":false,"given":"Pinghong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"284","article-title":"Needle\u2010based confocal laser endomicroscopy. 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