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Liver resection and liver transplantation (LT) are effective treatments for individuals with liver failure, liver cirrhosis and liver cancers. The remnant or transplanted liver tissues will undergo hepatic ischaemia\/reperfusion (IR), which leads to oxidative stress, inflammation, immune injury and liver damage. Moreover, systemic ischaemia induced by trauma, stroke, myocardial ischaemia, haemorrhagic shock and other injury factors also induces liver ischaemia\/reperfusion injury (IRI) in individuals. Hepatic IRI can be divided into warm IRI, which is induced by liver surgery and systemic ischaemia, and cold IRI, which is induced by LT. Multiple studies have shown that melatonin (MT) acts as an endogenous free radical scavenger with antioxidant capacity and is also able to attenuate hepatic IRI via its anti\u2010inflammatory and antiapoptotic capacities. In this review, we discuss the potential mechanisms and current strategies of MT administration in liver surgery for protecting against warm or cold hepatic IRI. We highlight strategies to improve the efficacy and safety of MT for attenuating hepatic IRI in different conditions. After the potential mechanisms underlying the interactions between MT and other important cellular processes during hepatic IR are clarified, more opportunities will be available to use MT to treat liver diseases in the future.<\/jats:p>","DOI":"10.1111\/cpr.13021","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T08:53:20Z","timestamp":1615366400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Melatonin and its protective role in attenuating warm or cold hepatic ischaemia\/reperfusion injury"],"prefix":"10.1111","volume":"54","author":[{"given":"Chenxia","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China"},{"name":"National Clinical Research Center for Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Kidney Disease Prevention and Control Technology Kidney Disease Center Institute of Nephrology First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China"},{"name":"National Clinical Research Center for Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 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